Indications

Cofnil Plus is indicated for chest congestion, cough & sore throat.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Composition

Each 5 ml syrup contains-

• Guaifenesin BP 200 mg
• Dextromethorphan Hydrobromide BP 15 mg
• Menthol USP 15 mg

Pharmacology

Guaifenesin is an expectorant. It helps loosen congestion in the chest and throat, making it easier to cough out through the mouth. Dextromethorphan Hydrobromide is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Menthol is an organic compound made synthetically or obtained from corn mint, peppermint or other mint oils. It has local anesthetic and counter irritant qualities and it is widely used to relieve throat irritation.

Dosage & Administration

Adult use: Only (12 years and over) 2 tea spoonful syrup (10 ml) every 6 hours.
Maximum dose: 8 tea spoonful syrup (40 ml)/day.
Pediatric use: Do not use for children less than 12 years of age.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Interaction

Possible reactions systemically may occur with acetaminophen or hydrocodone, diphenhydramine, escitalopram, acetaminophen or codeine, alprazolam & ondansetron.

Contraindications

If you are now taking a monoamine oxidase inhibitor (MAOI) or for two weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI ask a doctor or pharmacist before taking this product.

Side Effects

Common side effects are dizziness, drowsiness, gastrointestinal disturbance, feeling nervous, restless, anxious or irritable.

Pregnancy & Lactation

Dextromethorphan Hydrobromide and Guaifenesin have been assigned to pregnancy category C by the FDA. There are no controlled data on this combination product in human pregnancy. Dextromethorphan Hydrobromide and Guaifenesin is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of Dextromethorphan Hydrobromide and Guaifenesin into human milk. In nursing mothers, a decision should be made to discontinue. There are no human studies on the use of Menthol during pregnancy, thus, its risk is undetermined.

Precautions & Warnings

Talk to a doctor or pharmacist before using Cofnil Plus if you have asthma, chronic lung disease/ shortness of breath, persistent/ chronic cough or taking a drug for depression, including monoamine oxidase (MAO) inhibitor drugs.

Overdose Effects

Overdose with Guaifenesin is unlikely to produce toxic effect since its toxicity is low. In severe cases of overdose, treatment should be aimed at reducing further absorption of the drug. Gastric emptying is recommended as soon as possible after ingestion. Overdose with Dextromethorphan Hydrobromide may produce excitement and mental confusion. Very high doses may produce respiratory depression. One case of toxic psychosis after ingestion of a single 300 mg dose of Dextromethorphan Hydrobromide has been reported. Menthol can be harmful in large amounts. Symptoms may include abdominal pain, diarrheoa, nausea and vomiting, dizziness, rapid breathing etc.

Therapeutic Class

Combined cough expectorants, Combined cough suppressants

Storage Conditions

Store in a cool (below 30°C) and dry place, away from light. Keep out of the reach of children.