Inhouse product
Indications
Luraprex is indicated
for:
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
The mechanism of
action of Lurasidone in the treatment of schizophrenia and bipolar depression
is unknown. However, its efficacy in schizophrenia and bipolar depression could
be mediated through a combination of central dopamine Type 2 (D2) and serotonin
Type-2 (5HT2A) receptor antagonism.
Dosage & Administration
Lurasidone should be
taken with food (at least 350 calories). Administration with food substantially
increases the absorption of Lurasidone
Schizophrenia: The recommended starting dose of Lurasidone
is 40 mg once daily. Initial dose titration is not required. The maximum
recommended dose is 160 mg per day.
Depressive Episodes
Associated with Bipolar I Disorder: The recommended starting dose of Lurasidone is 20 mg given
once daily as monotherapy or as adjunctive therapy with lithium or valproate.
Initial dose titration is not required. The maximum recommended dose, as
monotherapy or as adjunctive therapy with lithium or valproate, is 120 mg per
day.
Pediatric Use: Safety and effectiveness in pediatric
patients have not been established.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Luraprex should not be
used concomitantly with strong CYP3A4 inhibitors (e.g., ketoconazole,
clarithromycin, ritonavir, voriconazole, mibefradil, etc.) or strong CYP3A4
inducers (e.g., rifampin, phenytoin, carbamazepine, etc.)
Contraindications
Lurasidone is
contraindicated in patients who have demonstrated hypersensitivity to the drug
or its ingredients. It is also contraindicated in concomitant use with a strong
CYP3A4 inhibitor (e.g. ketoconazole) & a strong CYP3A4 inducer (e.g.,
rifampin).
Side Effects
Commonly observed
adverse reactions are-somnolence, akathisia, extrapyramidal symptoms, and
nausea etc.
Pregnancy & Lactation
Pregnancy Category B.
Nursing mothers: Lurasidone is excreted in human milk. Because of the potential
for serious adverse reactions in nursing infants from Lurasidone, a decision
should be made whether to discontinue nursing or discontinue the drug, taking
into account the importance of the drug to the mother.
Precautions & Warnings
It can cause increased
mortality in elderly patients with dementia-related psychosis, increase
suicidal thoughts and behaviors in adolescents and young adults.
Therapeutic Class
Atypical neuroleptic
drugs
Storage Conditions
Store at temperature
not exceeding 30°C in a dry place. Protect from light.
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