Arixon 500 mg/vial is a third-generation cephalosporin antibiotic designed for the treatment and prevention of a wide range of bacterial infections. It provides broad-spectrum activity against both Gram-positive and Gram-negative bacteria and is effective in serious infections requiring parenteral administration. Arixon works by inhibiting bacterial cell wall synthesis, leading to bactericidal activity. Its long plasma half-life allows for once- or twice-daily dosing, making it a convenient option for inpatient and outpatient therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Third-Generation Cephalosporin / Parenteral Antibiotic

Indications

Arixon 500 mg/vial is indicated for the treatment of:

• Lower respiratory tract infections such as pneumonia and bronchitis

• Acute bacterial otitis media

• Skin and soft tissue infections

• Urinary tract infections

• Gonorrhea

• Bacterial septicemia

• Bone and joint infections

• Meningitis

• Prevention of postoperative infections

• Perioperative prophylaxis for surgical procedures

Pharmacology and Mode of Action

Arixon 500 mg/vial is a broad-spectrum cephalosporin that exhibits potent bactericidal activity by interfering with bacterial cell wall synthesis. It is stable against beta-lactamases, allowing efficacy against a wide variety of resistant bacteria.

• Absorption & Distribution: Administered intravenously or intramuscularly, Arixon distributes widely in body tissues and fluids.

• Metabolism: The drug is not metabolized; 40–65% is excreted unchanged in urine, and the remainder via bile.

• Protein Binding: Highly protein-bound (≈95%).

• Half-Life: Approximately 6–9 hours, supporting convenient dosing schedules.

Dosage and Administration

Adults:

• General infections: 1–2 g IV or IM once daily, or divided into twice-daily doses

• Maximum dose: 4 g/day

• Uncomplicated gonococcal infections: 250 mg IM as a single dose

• Surgical prophylaxis: 1 g IV 30–120 minutes before surgery

Infants and Children (≥1 month):

• General infections: 50–75 mg/kg IV or IM once daily (or divided twice daily), max 2 g/day

• Acute otitis media: 50 mg/kg IM single dose, max 1 g/day

• Meningitis: 100 mg/kg IV or IM once daily or divided twice daily, max 4 g/day

Duration of Therapy: Usually 4–14 days; may extend in complicated infections. Continue for at least 2 days after clinical resolution.

Preparation for Injection:

• IM Injection: Dissolve in Lidocaine HCl 1% (2–3.5 ml depending on dose)

• IV Injection: Dissolve in Water for Injection (5–20 ml depending on dose) and administer over 2–4 minutes or as a 30-minute infusion.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to cephalosporins or beta-lactam antibiotics

Side Effects

• Gastrointestinal: Diarrhea, nausea, vomiting, stomatitis

• Skin: Rash, pruritus, urticaria, erythema multiforme

• Hematologic: Eosinophilia, thrombocytopenia, leukopenia, anemia

• Hepatic: Elevated SGOT/SGPT, bilirubinemia

• CNS: Headache, dizziness, confusion, convulsions

• Local: Phlebitis at IV site (rare, minimized by slow injection)

Precautions and Warnings

• Risk of anaphylactic reactions; immediate treatment with epinephrine and glucocorticoids if occurs

• Monitor blood counts during prolonged therapy

• Reversible gallbladder sludge has been reported; usually managed conservatively

• Not recommended in premature neonates or newborns ≤28 days

Pregnancy and Lactation

• Use only if clearly indicated; safety not established in pregnancy

• Low concentrations are excreted in breast milk; exercise caution

Overdose

• No specific antidote; treatment should be symptomatic and supportive

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.