Evo TS 1.5% is a broad-spectrum, third-generation fluoroquinolone antibiotic under the therapeutic class of 4-Quinolone preparations. It is formulated to provide effective antibacterial activity against a wide range of Gram-positive and Gram-negative pathogens. Evo TS 1.5% is indicated for the treatment of various mild to severe bacterial infections in adults, particularly when a potent and reliable antimicrobial agent is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Evo TS 1.5% is indicated for the treatment of the following infections in adults (18 years of age and above):

• Respiratory tract infections, including:

  • Acute bacterial sinusitis

  • Acute exacerbation of chronic bronchitis

  • Community-acquired pneumonia

  • Nosocomial (hospital-acquired) pneumonia

• Uncomplicated and complicated skin and soft tissue infections

• Chronic bacterial prostatitis

• Uncomplicated and complicated urinary tract infections (mild to moderate)

Pharmacology

Evo TS 1.5% is a synthetic, chiral fluorinated carboxyquinolone antibiotic. It exerts its antibacterial effect by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential enzymes for bacterial DNA replication, transcription, repair, and recombination. Inhibition of these enzymes prevents bacterial cell division, resulting in rapid bacterial cell death. Evo TS 1.5% demonstrates strong in-vitro activity against a broad spectrum of Gram-positive and Gram-negative microorganisms.

Dosage and Administration

The dosage regimen depends on the type and severity of the infection:

• Acute sinusitis: 500 mg once daily for 10–14 days

• Acute exacerbation of chronic bronchitis: 250–500 mg once daily for 7–10 days

• Community-acquired pneumonia: 500 mg once or twice daily for 7–14 days

• Nosocomial pneumonia: 750 mg once daily for 7–14 days

• Skin and soft tissue infections: 500 mg once or twice daily for 7–14 days

• Chronic bacterial prostatitis: 500 mg once daily for 28 days

• Urinary tract infections:

  • 250 mg once daily for 7–10 days

  • 250 mg once daily for 3 days in uncomplicated infections

Dose adjustment is required in patients with impaired renal function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Antacids, iron preparations, and adsorbents may reduce the absorption of Evo TS 1.5%

• Concurrent use with NSAIDs may increase the risk of central nervous system stimulation

• Warfarin may increase the risk of bleeding when administered with Evo TS 1.5%

Contraindications

Evo TS 1.5% is contraindicated in patients with a known history of hypersensitivity to fluoroquinolone antibiotics or any component of this formulation.

Side Effects

Evo TS 1.5% is generally well tolerated. Commonly observed side effects include:

• Nausea

• Vomiting

• Diarrhea

• Abdominal pain

• Flatulence

Rarely, phototoxic reactions may occur. Very rare adverse effects include tremors, anxiety, depression, confusion, and other central nervous system disturbances.

Pregnancy and Lactation

Evo TS 1.5% is classified as US FDA pregnancy category C. It should be avoided during pregnancy and lactation unless the potential benefit clearly outweighs the possible risks to the fetus or infant.

Precautions and Warnings

• Adequate hydration should be maintained during therapy to prevent concentrated urine

• Caution is advised in patients with renal impairment

• Dose adjustment is necessary in renal dysfunction

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.