Influvax Tetra 0.5 ml Prefilled Syringe is a quadrivalent inactivated influenza vaccine designed for the prevention of influenza (flu) in adults and children. It provides protection against four strains of the influenza virus, including two influenza A strains and two influenza B strains, helping to reduce the risk of flu-related complications. The vaccine stimulates the immune system to produce antibodies, providing immunity before exposure to circulating influenza viruses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Vaccines, Anti-sera & Immunoglobulin

Composition

Each 0.5 ml dose contains inactivated influenza virus antigens (haemagglutinin) propagated in fertilized hen’s eggs:

• A/California/07/2009 (H1N1)-like strain: 15 μg

• A/Perth/16/2009 (H3N2)-like strain: 15 μg

• B/Brisbane/60/2008-like strain: 15 μg

• B strain (additional B lineage depending on season): 15 μg

The vaccine is inactivated with formaldehyde and contains minimal residues from eggs or other manufacturing components.

Indications

• Prophylaxis of influenza: Recommended especially for individuals at increased risk of complications, including:

  • Elderly individuals

  • Pregnant women

  • People with chronic medical conditions

  • Healthcare workers

• Vaccination should be aligned with official health authority recommendations and repeated annually with updated vaccine strains.

Pharmacology

Influvax Tetra 0.5 ml promotes immunity by inducing specific antibody production against influenza virus surface antigens (haemagglutinin and neuraminidase). Antibodies neutralize the virus upon exposure, preventing infection or reducing the severity of illness. Seroprotection is typically achieved within 2–3 weeks and lasts approximately 6–12 months, depending on viral strain match and individual immune response.

Dosage & Administration

• Adults and children ≥3 years: 0.5 ml once annually

• Children 6–36 months: 0.25 ml; children not previously vaccinated require a second dose after at least 4 weeks

• Route: Intramuscular injection, preferably into the deltoid muscle

• Shake the syringe gently and allow to reach room temperature before use.

• Vaccination should be given before the onset of influenza season or as recommended based on epidemiological data.

Drug Interactions

• May be co-administered with other vaccines on separate limbs; adverse effects may be intensified.

• Immunosuppressive therapy may reduce vaccine efficacy.

• Transient false-positive results in ELISA serology tests for HIV, Hepatitis C, and HTLV1 may occur; confirmed by Western Blot.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to influenza antigens or any excipients (including egg proteins, kanamycin, neomycin, formaldehyde, polysorbate 80)

• Acute febrile illness: vaccination should be postponed

Side Effects

• Local reactions: Redness, swelling, pain, induration at injection site

• Systemic reactions: Fever, fatigue, shivering, headache, myalgia, arthralgia, rash

• Rare reactions: Anaphylaxis, vasculitis, neurological disorders

• Most reactions resolve within 1–2 days without treatment

Pregnancy & Lactation

• Safe for use in pregnancy when benefits outweigh potential risks; recommended from the second trimester in high-risk women.

• Can be administered during lactation.

Precautions & Warnings

• Immunocompromised patients may have insufficient antibody response

• Ensure emergency medical treatment is available in case of anaphylaxis

• Never administer intravascularly

Storage Conditions

• Store in a refrigerator at 2°C–8°C

• Do not freeze

• Keep in the outer carton to protect from light

• Dispose of unused vaccine or waste according to local regulations.