Intafenac K 50 mg is primarily indicated for the short-term treatment of acute pain and inflammation in various conditions:

1. Post-traumatic pain, inflammation, and swelling – e.g., sprains, strains, or injuries.

2. Post-operative pain, inflammation, and swelling – e.g., following dental, orthopedic, or other surgical procedures.

3. Gynaecological painful and inflammatory conditions – e.g., primary dysmenorrhoea (menstrual cramps), adnexitis.

4. Migraine attacks – to relieve acute migraine episodes.

5. Painful syndromes of the vertebral column – e.g., back pain or sciatica.

6. Non-articular rheumatism – pain and inflammation in muscles, ligaments, or soft tissues.

7. Adjuvant therapy for severe infections of the ear, nose, or throat – e.g., pharyngotonsillitis, otitis media with pain and inflammation.

   রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

• Drugs used for Rheumatoid Arthritis

• Drugs for Osteoarthritis

Pharmacology

Diclofenac, the active component of Intafenac K, works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2). These enzymes are responsible for the production of prostaglandins, which mediate pain, inflammation, and fever. By reducing prostaglandin synthesis:

• Pain signaling in peripheral nerves is diminished.

• Inflammation and swelling are reduced.

• Fever and sensitization of tissues to pain-inducing agents (e.g., bradykinin) are alleviated.

Diclofenac is potent both in vitro (lab studies) and in vivo (in patients), providing effective relief for acute inflammatory conditions.

Dosage & Administration

Adults:

• Initial loading dose: 50 mg

• Maintenance: 25–50 mg every 8 hours if needed

• Maximum daily dose: 150 mg

For migraine attacks:

• Initial 50 mg, then 25–50 mg after 2 hours if needed

Children over 14 years:

• Up to 75 mg daily in divided doses

Administration:

• Swallow tablets whole with liquid, preferably before meals.

Drug Interactions

• Lithium & Digoxin: Plasma concentrations may increase.

• Anticoagulants: Increased risk of bleeding.

• Cyclosporin: Risk of nephrotoxicity.

• Methotrexate: Serious toxicity if given within 24 hours of Diclofenac.

• Diuretics: May reduce their effectiveness.

• Other NSAIDs or steroids: Increased frequency of adverse effects.

Contraindications

• Hypersensitivity to Diclofenac

• History of asthma, urticaria, or allergic reactions to aspirin or NSAIDs

• Perioperative pain in coronary artery bypass graft (CABG) surgery

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

• Common/Occasional: Epigastric pain, nausea, vomiting, diarrhea, dyspepsia, abdominal cramps, flatulence

• Rare: Gastrointestinal bleeding, peptic ulcer, bloody diarrhea

• If serious adverse effects occur, discontinue the drug

Pregnancy & Lactation

• Avoid during pregnancy unless necessary; not recommended in the last trimester

• Small quantities may pass into breast milk; generally safe, but caution is advised

Storage Conditions

• Store below 30°C, away from light and moisture

• Keep out of reach of children.