Kilbac 125 mg is a second-generation cephalosporin antibiotic containing Cefuroxime, a broad-spectrum bactericidal agent effective against a wide range of bacterial infections, including β-lactamase-producing strains. It is widely used to treat respiratory tract infections, skin and soft tissue infections, urinary tract infections, bone and joint infections, and certain sexually transmitted infections, among others. Kilbac 125 mg is suitable for oral and parenteral use, providing flexibility for both outpatient and hospital-based treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Kilbac 125 mg is indicated for the treatment of infections caused by Cefuroxime-sensitive bacteria, including:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes

• Acute Bacterial Otitis Media: Caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes

• Acute Bacterial Maxillary Sinusitis: S. pneumoniae, H. influenzae (non-beta-lactamase producing strains)

• Lower Respiratory Tract Infections: Including community-acquired pneumonia, caused by S. pneumoniae, H. influenzae, Klebsiella spp., S. aureus, E. coli

• Acute Exacerbation of Chronic Bronchitis and secondary bacterial infections of acute bronchitis

• Skin and Skin-Structure Infections: Caused by S. aureus (including beta-lactamase-producing strains) and S. pyogenes

• Urinary Tract Infections: Caused by E. coli or Klebsiella pneumoniae

• Bone and Joint Infections: Caused by S. aureus

• Gonorrhoea: Caused by penicillinase-producing and non-penicillinase-producing Neisseria gonorrhoeae

• Early Lyme Disease (Erythema Migrans): Caused by Borrelia burgdorferi

Pharmacology

Cefuroxime exhibits broad-spectrum bactericidal activity by inhibiting bacterial cell wall synthesis. It is stable against many bacterial β-lactamases, which allows it to be effective against ampicillin- and amoxicillin-resistant strains. The drug is effective in both oral and parenteral forms and treats infections caused by a variety of gram-positive and gram-negative bacteria.

Dosage and Administration

Oral (Tablet/Suspension):

• Adults (≥13 years):

  • Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

  • Acute bacterial sinusitis: 250 mg twice daily for 10 days

  • Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

  • Urinary tract infections: 250 mg twice daily for 7–10 days

  • Early Lyme disease: 500 mg twice daily for 20 days

• Pediatric (3 months–12 years):

  • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d.

  • Otitis media, sinusitis, impetigo: 30 mg/kg/day b.i.d.

Parenteral (IM/IV):

• Adults: 750 mg 3x daily; may increase up to 1.5 g 3x daily for severe infections

• Children: 30–100 mg/kg/day in divided doses

• Surgical prophylaxis: 1.5 g IV at induction, with additional doses as needed

Reconstitution:

• 750 mg IM: Add 3 ml water for injection

• 750 mg IV: Add 8 ml water for injection

• 1.5 g IV: Add 16 ml water for injection

• Inject slowly over 3–5 minutes

Contraindications

• Known hypersensitivity to cephalosporins

Side Effects

• Gastrointestinal disturbances (nausea, diarrhea)

• Skin rashes

• Overgrowth of non-susceptible organisms with prolonged use

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use with caution in patients with history of colitis or on potent diuretics

• Cephalosporins may rarely cause cross-reactivity in penicillin-allergic patients

Pregnancy and Lactation

• Pregnancy Category B (FDA): Use only if clearly needed

• Excreted in human milk; caution advised for nursing mothers

Storage Conditions

• Store below 30°C, away from light and moisture

• Keep out of reach of children.