Klarix 250 mg is a macrolide antibiotic formulated with Clarithromycin, widely used for the treatment of a variety of bacterial infections affecting the respiratory tract, skin, and soft tissues. It is also an important component of combination therapy for the eradication of Helicobacter pylori in patients with duodenal ulcers. Klarix 250 mg offers improved acid stability and better gastrointestinal tolerability compared to erythromycin, making it a reliable option in both adult and pediatric populations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Macrolides

Indications

Klarix 250 mg is indicated for the treatment of infections caused by susceptible organisms, including:

• Upper Respiratory Tract Infections

  • Streptococcal pharyngitis

  • Acute sinusitis

• Lower Respiratory Tract Infections

  • Infective exacerbations of chronic bronchitis

  • Community-acquired pneumonia

  • Atypical pneumonia

• Skin and Soft Tissue Infections

  • Mild to moderate infections of the skin and underlying soft tissues

• Gastrointestinal Infections

  • Adjunct therapy in the eradication of Helicobacter pylori in patients with duodenal ulcers

Pharmacology

Clarithromycin acts by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, blocking translocation and thereby preventing the growth of susceptible organisms. Klarix 250 mg is active against most Gram-positive bacteria, Chlamydia, Mycoplasma, and selected Gram-negative organisms. It demonstrates greater in vitro activity than erythromycin against many Gram-positive bacteria and has approximately twice the activity against Haemophilus influenzae. Due to limited penetration, most Gram-negative bacteria remain resistant.

Dosage and Administration

Adults:

• Pharyngitis/Tonsillitis: 250 mg every 12 hours for 10 days

• Acute maxillary sinusitis: 500 mg every 12 hours for 14 days

• Chronic bronchitis: 250–500 mg every 12 hours for 7–14 days

• Pneumonia: 250 mg every 12 hours for 7–14 days

• Uncomplicated skin and soft tissue infections: 250 mg every 12 hours for 7–14 days

• Community-acquired upper and lower respiratory tract infections: 250–500 mg every 12 hours for 5–14 days

Children:

• Bodyweight under 8 kg: 7.5 mg/kg twice daily

• 8–11 kg (1–2 years): 2.5 ml twice daily

• 12–19 kg (3–6 years): 5 ml twice daily

• 20–29 kg (7–9 years): 7.5 ml twice daily

• 30–40 kg (10–12 years): 10 ml twice daily

Administration

Klarix 250 mg may be administered with or without meals.

Drug Interactions

• Theophylline: Concomitant use may increase serum theophylline levels.

• Terfenadine: Clarithromycin may interfere with terfenadine metabolism, increasing the risk of cardiac adverse effects.

Contraindications

• Known hypersensitivity to clarithromycin, erythromycin, or other macrolide antibiotics

• Patients receiving terfenadine with pre-existing cardiac abnormalities or electrolyte disturbances

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Klarix 250 mg is generally well tolerated. Reported side effects include:

• Nausea, vomiting, diarrhoea, and abdominal pain

• Stomatitis and glossitis

• Headache and taste perversion

• Allergic reactions ranging from mild skin rashes to anaphylaxis

• Rare transient central nervous system effects such as dizziness, anxiety, insomnia, and hallucinations

Pregnancy and Lactation

Klarix 250 mg is not recommended during pregnancy due to limited clinical data. Breastfeeding should be avoided during treatment, as clarithromycin is excreted in breast milk.

Precautions and Warnings

• Use with caution in patients with hepatic or renal impairment

• Prolonged or repeated use may lead to overgrowth of non-susceptible organisms, including fungi

• Discontinue treatment and initiate appropriate therapy if superinfection occurs

Overdose

Overdose may result in gastrointestinal symptoms. Rare cases have reported altered mental status and electrolyte imbalance following large ingestions. Management includes supportive care and elimination of unabsorbed drug. Haemodialysis and peritoneal dialysis are not effective in significantly reducing serum clarithromycin levels.

Use in Special Populations

Klarix 250 mg may be used in neonates and children at appropriate dose levels.

Duration of Treatment

• Adults and children over 12 years: Typically 6–14 days

• H. pylori eradication in duodenal ulcers: Usually 6–14 days as part of combination therapy

Storage Conditions

Store in a cool, dry place, protected from light and moisture.
Reconstituted suspension should be used within 7 days at room temperature or within 14 days if refrigerated. Keep out of reach of children.

Reconstitution

Add 45 ml of water to the granules in the bottle and shake well to prepare 70 ml of suspension.
Each 5 ml of the reconstituted suspension contains clarithromycin 125 mg.