Zopilone 1 mg, containing the active ingredient Eszopiclone, is a prescription hypnotic used to treat insomnia. It helps individuals fall asleep faster, reduce nighttime awakenings, and improve overall sleep quality. Zopilone is part of the non-benzodiazepine “Z-drugs” class and offers effective short-term management of sleep disturbances while minimizing the risk of dependence compared to traditional benzodiazepines.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Non-benzodiazepine hypnotics (Z-drugs)

Indications

Zopilone 1 mg is indicated for:

• Short-term treatment of insomnia characterized by difficulty falling asleep

• Reducing nighttime awakenings and improving sleep maintenance

• Enhancing overall sleep quality and daytime alertness

It is not recommended for use in children under 18 years of age and should be used with caution in elderly or debilitated patients.

Pharmacology

Eszopiclone, the active component of Zopilone 1 mg, selectively binds to the GABA-A receptor complex at the benzodiazepine-binding site. By enhancing the inhibitory effects of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter in the CNS, it induces sedation and promotes sleep.

• Rapid onset of action: peak plasma concentration occurs within 1 hour

• Short half-life: approximately 6 hours, minimizing next-day sedation

• Metabolism occurs primarily via hepatic cytochrome P450 enzymes, including CYP3A4

Zopilone 1 mg helps regulate sleep architecture by reducing sleep latency and nighttime awakenings while minimally affecting REM sleep.

Dosage and Administration

• Adults: 1 mg immediately before bedtime; maximum recommended dose is 3 mg per night

• Elderly or debilitated patients: Start with 1 mg; dose may be adjusted based on tolerance

• Administration: Tablets should be swallowed whole with water; do not crush or chew

• Timing: Take only when able to get at least 7–8 hours of sleep before planned awakening

Zopilone is intended for short-term use, typically 2–4 weeks, though longer durations may be considered under physician supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Interactions

• CNS depressants: Alcohol, antihistamines, sedatives, or other hypnotics can increase sedative effects

• CYP3A4 inhibitors/inducers: Ketoconazole, rifampicin, or St. John’s Wort may alter Zopilone metabolism

• Other drugs: Concomitant use with other sleep-inducing medications should be monitored carefully

Contraindications

Zopilone 1 mg is contraindicated in patients with:

• Hypersensitivity to Eszopiclone or other ingredients

• Severe hepatic impairment

• History of complex sleep behaviors (sleep-driving, sleep-eating)

• Myasthenia gravis, respiratory depression, or sleep apnea

Side Effects

Common adverse effects:

• Drowsiness, dizziness, headache, fatigue

• Unpleasant taste (dysgeusia)

• Mild gastrointestinal discomfort

Less common but serious side effects include:

• Complex sleep behaviors (sleep-driving, sleep-walking)

• Memory impairment or next-day psychomotor deficits

Precautions & Warnings

• Avoid activities requiring full alertness (driving, operating machinery) the night of dosing

• Use with caution in patients with a history of depression, substance abuse, or respiratory disease

• Abrupt discontinuation may cause rebound insomnia or anxiety

• Potential for dependence exists with prolonged use

Use in Special Populations

• Pregnancy: Category C; only use if potential benefit outweighs risk

• Lactation: Excreted in breast milk; nursing not recommended during therapy

• Elderly: Lower starting dose recommended due to increased sensitivity

Overdose

Symptoms: excessive sedation, confusion, respiratory depression, impaired coordination
Management: supportive care, monitoring of vital signs, and gastric lavage if necessary

Storage

Store in a cool, dry place below 30°C, away from light and moisture. Keep out of the reach of children.

Mode of Action

Zopilone 1 mg binds to GABA-A receptor complexes, enhancing GABAergic neurotransmission. This increases chloride ion influx, hyperpolarizes neurons, reduces CNS excitability, and promotes sleep initiation and maintenance without significant disruption of normal sleep architecture.