Abevmy IV Infusion 400 mg/16 ml contains Bevacizumab, a recombinant humanized monoclonal antibody used in the treatment of several types of cancers. Bevacizumab works by targeting and inhibiting vascular endothelial growth factor (VEGF), a key protein responsible for the formation of new blood vessels (angiogenesis). By blocking VEGF, Abevmy helps restrict the blood supply to tumors, thereby slowing tumor growth and progression.

Abevmy is administered as an intravenous infusion and is typically used in combination with other anticancer medicines such as chemotherapy, depending on the type and stage of cancer. It is prescribed and administered under the supervision of experienced healthcare professionals in specialized medical settings.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Antineoplastic Agent
Anti-angiogenic Therapy
Monoclonal Antibody

Indications

Abevmy IV Infusion is indicated for the treatment of various malignancies, including:

• Metastatic colorectal cancer

• Non-small cell lung cancer (NSCLC)

• Renal cell carcinoma

• Glioblastoma

• Cervical cancer

• Ovarian, fallopian tube, or primary peritoneal cancer

The exact indication and treatment regimen depend on the patient’s clinical condition and oncologist’s recommendation.

Pharmacology

Bevacizumab binds selectively to VEGF-A, preventing it from interacting with its receptors (VEGFR-1 and VEGFR-2) on endothelial cells. This inhibition suppresses the formation of new blood vessels within tumors, leading to reduced tumor oxygenation and nutrient supply. As a result, tumor growth is slowed and the effectiveness of other anticancer therapies may be enhanced.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Abevmy is given as an intravenous infusion only

• Dosage and infusion schedule vary based on cancer type, body weight, and treatment protocol

• Initial infusions are administered slowly, with subsequent infusions adjusted based on tolerance

• Must be administered by trained healthcare professionals

Possible Side Effects

Some patients may experience side effects, which can vary in severity. Commonly reported adverse effects include:

• High blood pressure

• Fatigue

• Diarrhea

• Nausea and vomiting

• Protein in urine

• Headache

Serious but less common side effects may include bleeding, gastrointestinal perforation, impaired wound healing, and thromboembolic events. Patients should be closely monitored during treatment.

Precautions and Warnings

• Not recommended during pregnancy due to risk of fetal harm

• Use with caution in patients with cardiovascular disease or uncontrolled hypertension

• Surgical procedures should be carefully timed due to impaired wound healing risk

• Regular monitoring of blood pressure and urine protein is advised

Storage

• Store under refrigeration at 2°C to 8°C

• Do not freeze

• Protect from light

• Keep out of reach of children.