Alpatin 0.05% is a sterile ophthalmic solution containing Epinastine, a potent topical antihistamine designed for the treatment of allergic eye conditions. It effectively relieves symptoms such as itching, redness, and irritation caused by allergic reactions affecting the anterior segment of the eye. With its dual action as an H1 and H2 receptor antagonist and mast cell stabilizer, Alpatin helps prevent the release of inflammatory mediators while minimizing systemic side effects. Its formulation ensures rapid relief while being safe for regular ophthalmic use.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Alpatin 0.05% is indicated for the management of:

• Allergic conjunctivitis

• Seasonal or perennial allergic eye disorders

• Signs and symptoms of anterior segment eye allergies, including itching, redness, and irritation

Therapeutic Class

Ophthalmic Non-Steroid Drugs

Pharmacology

Epinastine, the active ingredient in Alpatin, is a topically active antihistamine that:

• Antagonizes H1 and H2 histamine receptors to block allergic responses

• Exhibits mast cell stabilizing activity, preventing the release of histamine and other inflammatory mediators from blood vessels

• Does not cross the blood-brain barrier, minimizing the risk of central nervous system side effects such as drowsiness or sedation

This dual action provides both immediate relief from allergy symptoms and long-term control of ocular inflammation.

Dosage and Administration

• Recommended Dose: Instill 1 drop in each affected eye twice daily

• Duration: Continue treatment throughout allergen exposure (e.g., pollen season), even if symptoms are absent

• Shake well before use and follow proper eye drop administration techniques

Contraindications

Alpatin 0.05% is contraindicated in patients with:

• Known hypersensitivity to Epinastine or any component of the formulation

Side Effects

Common side effects are usually mild and include:

• Burning or stinging sensation in the eye

• Folliculosis (small bumps on the conjunctiva)

• Eye redness (hyperemia)

• Itching (pruritus)

• Cold-like symptoms or upper respiratory infections

Severe reactions are rare.

Precautions and Warnings

• For ophthalmic use only

• Avoid contact lens use if eyes are red or irritated

• Use with caution in pediatric patients under 3 years (safety not established)

• No significant differences in safety or efficacy have been observed in elderly patients

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

• Pregnancy: Use only if the potential benefit justifies the risk to the fetus

• Lactation: Unknown if Epinastine is excreted in human milk; exercise caution

Storage Conditions

• Store in a cool, dry place, protected from light

• Do not use for more than one month after opening

• Keep out of reach of children

Mode of Action

Epinastine works by blocking histamine H1 and H2 receptors and stabilizing mast cells in the eye, preventing the release of inflammatory mediators. Its action is limited to the site of application, with minimal systemic absorption, reducing the risk of central nervous system side effects.

Pediatric and Geriatric Use

• Pediatric: Safety and effectiveness not established for children under 3 years

• Geriatric: No differences in efficacy or safety compared to younger adults.