Apuldon Tablet 10 mg contains Domperidone Maleate, a dopamine receptor antagonist with prokinetic and antiemetic properties. It is used for the treatment of nausea and vomiting and to relieve symptoms associated with delayed gastric emptying (gastroparesis). By improving stomach motility, it helps reduce nausea, vomiting, bloating, early satiety, and upper abdominal discomfort, allowing food to move more efficiently through the digestive system.

Domperidone works by blocking dopamine (D2) receptors in the chemoreceptor trigger zone (CTZ), which helps prevent nausea and vomiting. It also enhances the contractions of the stomach and upper intestines, promoting faster gastric emptying without affecting normal gastric secretions. Unlike some other antiemetic medications, Domperidone has limited penetration into the central nervous system, making neurological side effects less common.

Apuldon Tablet is commonly prescribed for adults and adolescents to manage nausea and vomiting caused by gastrointestinal disorders, medications, or delayed gastric emptying. It may also be used in patients with functional dyspepsia to relieve symptoms related to impaired gastrointestinal motility. The medicine should be used for the shortest duration necessary and only under the supervision of a registered physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Domperidone Maleate 10 mg

Indications

Apuldon Tablet is indicated for:

• Nausea and vomiting
• Delayed gastric emptying (gastroparesis)
• Functional dyspepsia
• Bloating and upper abdominal discomfort
• Early satiety associated with slow stomach emptying
• Gastrointestinal symptoms related to impaired gastric motility

How It Works

Domperidone blocks dopamine receptors in the digestive tract and the brain's vomiting center, reducing nausea and vomiting. It also stimulates stomach and upper intestinal movements, promoting faster gastric emptying and improving digestive comfort.

Dosage & Administration

• Use strictly as prescribed by a registered physician.
• Usually taken 15–30 minutes before meals and, if required, before bedtime.
• Swallow the tablet whole with water.
• Do not exceed the recommended dose or duration of treatment.
• Take the medicine at the same time each day for optimal results.

Possible Side Effects

Some patients may experience:

• Dry mouth
• Headache
• Dizziness
• Abdominal cramps
• Diarrhea
• Drowsiness

Rare but serious side effects include irregular heartbeat, QT prolongation, palpitations, fainting, or severe allergic reactions. Seek immediate medical attention if these occur.

Precautions

• Use cautiously in patients with liver impairment, heart disease, or electrolyte imbalance.
• Do not exceed the recommended dose, as higher doses may increase the risk of serious cardiac side effects.
• Inform your doctor if you are taking medicines that affect heart rhythm.
• Use during pregnancy and breastfeeding only if clearly recommended by a healthcare professional.
• Avoid prolonged use unless advised by your physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Apuldon Tablet may interact with:

• Macrolide antibiotics (e.g., erythromycin, clarithromycin)
• Azole antifungal medicines (e.g., ketoconazole, itraconazole)
• Certain antiarrhythmic medicines
• Other QT-prolonging drugs
• Dopamine agonists

Always inform your healthcare provider about all prescription medicines, over-the-counter drugs, and herbal supplements you are taking.

Storage

• Store below 30°C.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.