Apulset Injection 8 mg/4 ml contains Ondansetron, a potent antiemetic medicine used to prevent and treat nausea and vomiting associated with chemotherapy, radiotherapy, surgery, and certain medical conditions. It is intended for intravenous (IV) or intramuscular (IM) administration by qualified healthcare professionals.

Ondansetron belongs to the class of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists. It works by blocking serotonin receptors in both the gastrointestinal tract and the brain, preventing the nerve signals that trigger nausea and vomiting. This helps improve patient comfort, supports recovery, and reduces the risk of dehydration and electrolyte imbalance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 4 ml injection contains:

• Ondansetron 8 mg

Indications

Apulset Injection 8 mg/4 ml is indicated for the prevention and treatment of:

• Chemotherapy-induced nausea and vomiting (CINV)
• Radiotherapy-induced nausea and vomiting (RINV)
• Postoperative nausea and vomiting (PONV)
• Severe nausea and vomiting when oral therapy is not appropriate
• Drug-induced nausea and vomiting, as advised by a physician

How Apulset Injection Works

Ondansetron selectively blocks 5-HT3 receptors found in the gastrointestinal tract and the central nervous system. During chemotherapy, surgery, or illness, serotonin is released and activates these receptors, triggering the vomiting reflex.

By blocking these receptors, Apulset Injection:

• Prevents nausea before it starts
• Reduces the frequency and severity of vomiting
• Improves patient comfort during cancer treatment and postoperative recovery
• Helps maintain hydration and nutritional status
• Supports faster recovery from illness or surgery

Dosage and Administration

• Administer only by a qualified healthcare professional.
• May be given by intravenous (IV) or intramuscular (IM) injection as prescribed.
• The dose depends on the patient's age, body weight, medical condition, and the type of treatment being received.
• It is commonly administered before chemotherapy, radiotherapy, or surgery to prevent nausea and vomiting.
• Follow the physician's instructions regarding dosage and treatment duration.

Do not self-administer this injection.

Benefits of Apulset Injection

• Rapid onset of action for effective nausea and vomiting control
• Helps prevent chemotherapy-, radiotherapy-, and surgery-related nausea
• Suitable for patients unable to take oral medication
• Reduces the risk of dehydration and electrolyte imbalance
• Improves patient comfort and recovery
• Well tolerated when administered under medical supervision

Possible Side Effects

Some common side effects may include:

• Headache
• Constipation
• Dizziness
• Fatigue
• Injection site discomfort or redness

Rare but serious side effects include:

• Allergic reactions
• Irregular heartbeat (QT prolongation)
• Chest pain
• Severe dizziness or fainting
• Serotonin syndrome when used with certain medicines

Seek immediate medical attention if serious allergic or cardiac symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• For administration by healthcare professionals only.
• Inform your doctor if you have liver disease, heart disease, or electrolyte abnormalities.
• Use cautiously in patients taking medicines that may prolong the QT interval.
• Inform your healthcare provider if you are pregnant, planning pregnancy, or breastfeeding.
• Tell your doctor about all medicines you are taking to reduce the risk of drug interactions.

Storage

• Store below 30°C in a cool, dry place.
• Protect from light.
• Keep out of reach of children.
• Do not use if the solution appears discolored or contains visible particles.