Arixon 2 gm/vial is a third-generation cephalosporin antibiotic designed for the treatment of a wide range of bacterial infections. Its broad-spectrum activity includes potent action against both Gram-positive and Gram-negative bacteria, making it effective in serious infections such as lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, bacterial septicemia, meningitis, and gonorrhea.

Arixon works by inhibiting bacterial cell wall synthesis, leading to cell death. It is stable in the presence of beta-lactamases and has a long plasma half-life of 6–9 hours, allowing for convenient once or twice-daily dosing. The drug is primarily excreted unchanged in the urine, with a portion eliminated via bile, and is highly protein-bound (95%).

It is available as a parenteral formulation for intravenous or intramuscular administration, ensuring rapid and effective delivery in severe or complicated infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Arixon 2 gm/vial is indicated for:

• Lower respiratory tract infections (pneumonia, bronchitis)

• Acute bacterial otitis media

• Skin and skin structure infections

• Urinary tract infections

• Gonorrhea

• Bacterial septicemia

• Bone and joint infections

• Meningitis

• Prevention of postoperative infections

• Perioperative prophylaxis of infections associated with surgery

Therapeutic Class

• Third-generation Cephalosporins

Pharmacology

Arixon is a bactericidal antibiotic that inhibits bacterial cell wall synthesis. Its key features include:

• Broad-spectrum activity against Gram-positive and Gram-negative bacteria

• High beta-lactamase stability

• Long plasma half-life enabling convenient dosing

• Minimal metabolism; primarily excreted unchanged in urine and bile

Dosage and Administration

Adults:

• Usual dose: 1–2 g IV or IM once daily, or divided into two doses

• Maximum dose: 4 g/day

• Uncomplicated gonococcal infections: 250 mg IM as a single dose

• Surgical prophylaxis: 1 g IV 30–120 minutes before surgery

Infants and Children (≥1 month):

• 50–75 mg/kg IV or IM once daily, divided doses if needed

• Maximum dose: 2 g/day for most infections

• Acute bacterial otitis media: 50 mg/kg IM single dose (max 1 g/day)

• Meningitis: 100 mg/kg IV or IM once daily or divided doses (max 4 g/day)

Duration: 4–14 days typically; longer therapy for complicated infections.

Preparation:

• IM: Dissolve in Lidocaine HCl 1%

• IV: Dissolve in Water for Injection and administer slowly over 2–4 minutes or via infusion over 30 minutes

Note: A test dose may be recommended to check for hypersensitivity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• No significant drug interactions reported

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

Common and less common adverse effects may include:

• Gastrointestinal: diarrhea, nausea, vomiting, stomatitis, glossitis

• Cutaneous: rash, pruritus, urticaria, edema, erythema multiforme

• Hematologic: eosinophilia, thrombocytopenia, leukopenia, anemia, neutropenia

• Hepatic: elevated SGOT, SGPT, bilirubin

• CNS: headache, dizziness, sleep disturbances, hyperactivity, convulsions

• Local: rare phlebitis at IV site

Pregnancy and Lactation

• Safety not established in pregnancy; use only if necessary

• Low concentrations excreted in breast milk; exercise caution in nursing mothers

Precautions and Warnings

• Monitor for anaphylactic reactions; administer epinephrine and corticosteroids if needed

• Gallbladder sludge may occur but is usually reversible

• Monitor blood counts during prolonged therapy

Overdose

• No specific antidote; treatment is symptomatic and supportive

Storage Conditions

• Store below 30°C, in a dry place, protected from light and moisture

• Keep out of reach of children

Use in Special Populations

• Neonates: Avoid in premature and newborn infants (<28 days old).