Arixon 250 mg/vial is a third-generation cephalosporin antibiotic with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. It is used to treat a variety of bacterial infections and is suitable for intravenous or intramuscular administration. Arixon 250 mg/vial works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Its high stability against beta-lactamases and a long plasma half-life of 6–9 hours allows for convenient once- or twice-daily dosing.

This formulation is ideal for serious infections requiring parenteral therapy, including respiratory infections, urinary tract infections, skin infections, septicemia, and meningitis, as well as for perioperative prophylaxis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Arixon 250 mg/vial is indicated for the treatment of:

• Lower respiratory tract infections (pneumonia, bronchitis)

• Acute bacterial otitis media

• Skin and skin structure infections

• Urinary tract infections

• Gonorrhea

• Bacterial septicemia

• Bone and joint infections

• Meningitis

• Prevention of postoperative infections

• Perioperative prophylaxis of infections associated with surgery

Therapeutic Class

• Third-generation Cephalosporins

Pharmacology

Arixon 250 mg/vial is bactericidal and interferes with bacterial cell wall synthesis. Key pharmacological features include:

• Broad-spectrum activity against Gram-positive and Gram-negative organisms

• Resistance to many beta-lactamases

• Long plasma half-life allowing single or twice-daily dosing

• High protein binding (95%) and partial excretion unchanged in urine and bile

Dosage and Administration

Adults:

• Typical dose: 1–2 g IV or IM once daily or divided twice daily

• Maximum dose: 4 g/day

• Gonococcal infections: 250 mg IM single dose

• Surgical prophylaxis: 1 g IV 30–120 minutes before surgery

Infants and Children (≥1 month):

• 50–75 mg/kg IV or IM once daily, divided doses if required

• Maximum 2 g/day for most infections

• Acute otitis media: 50 mg/kg IM single dose (max 1 g/day)

• Meningitis: 100 mg/kg IV or IM once daily or divided doses (max 4 g/day)

Duration: Usually 4–14 days; longer for complicated infections.

Preparation:

• IM: Dissolve in Lidocaine HCl 1%

• IV: Dissolve in Water for Injection and administer over 2–4 minutes or by infusion over 30 minutes

Note: Patient tolerance test is recommended before initial administration. Freshly reconstituted solution is preferred.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• No clinically significant drug interactions reported

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

Possible adverse effects include:

• Gastrointestinal: diarrhea, nausea, vomiting, stomatitis, glossitis

• Cutaneous: rash, pruritus, urticaria, edema, erythema multiforme

• Hematologic: eosinophilia, thrombocytopenia, leukopenia, anemia, neutropenia

• Hepatic: elevated SGOT, SGPT, bilirubin

• CNS: headache, dizziness, sleep disturbances, hyperactivity, convulsions

• Local: rare phlebitis at injection site

Pregnancy and Lactation

• Safety in pregnancy not established; use only if necessary

• Low concentrations excreted in breast milk; caution in nursing mothers

Precautions and Warnings

• Risk of anaphylaxis; treat with IV epinephrine and corticosteroids if needed

• Gallbladder sludge may occur, typically reversible

• Monitor blood counts during prolonged therapy

Overdose

• No specific antidote; treatment is symptomatic and supportive

Storage Conditions

• Store below 30°C, protected from light and moisture

• Keep out of reach of children

Special Populations

• Neonates (<28 days): Avoid use, especially in premature infants