Axodin Oral Suspension 50 ml contains Fexofenadine Hydrochloride, a second-generation, non-sedating antihistamine used for the effective management of allergic conditions. This liquid formulation is especially suitable for children and patients who have difficulty swallowing tablets, while still providing reliable and long-lasting relief from allergy symptoms. Axodin works by targeting the underlying cause of allergic reactions without causing significant drowsiness, allowing patients to maintain normal daily activities.

Allergic conditions such as allergic rhinitis and chronic idiopathic urticaria are caused by the release of histamine in response to allergens like pollen, dust mites, animal dander, or other environmental triggers. Histamine binding to H1 receptors leads to symptoms such as sneezing, runny nose, watery eyes, itching, and skin wheals. Axodin Oral Suspension 50 ml selectively blocks peripheral H1 receptors, preventing histamine from producing these symptoms and improving overall comfort and quality of life.

Axodin 50 ml is indicated for the treatment of seasonal and perennial allergic rhinitis in adults and children aged 12 years and above. It effectively relieves sneezing, rhinorrhea, lacrimation, itchy and red eyes, and itching of the nose, palate, and throat. Regular use has been shown to enhance work and activity productivity and improve health-related quality of life. In addition, Axodin is recommended for the management of chronic idiopathic urticaria, where it significantly reduces the number of wheals and relieves persistent pruritus.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Non-sedating antihistamines

Pharmacology

Fexofenadine Hydrochloride is a selective peripheral H1-receptor antagonist. After oral administration, it is rapidly absorbed and reaches peak plasma concentration within 2 to 3 hours. It does not significantly cross the blood-brain barrier, which explains its minimal sedative and central nervous system effects compared to first-generation antihistamines.

Indications

• Seasonal allergic rhinitis

• Perennial allergic rhinitis

• Chronic idiopathic urticaria

• Relief from sneezing, runny nose, watery eyes, and itching

• Reduction of wheals and pruritus in chronic hives

Dosage and Administration

Allergic Rhinitis

• Adults and children ≥12 years:
  Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
  Renal impairment: 60 mg once daily

• Children 6–11 years:
  Tablet: 30 mg twice daily or 60 mg once daily
  Renal impairment: 30 mg once daily

• Children 2–11 years:
  Suspension: 30 mg (5 ml) twice daily
  Renal impairment: 30 mg (5 ml) once daily

Chronic Idiopathic Urticaria

• Adults and children ≥12 years:
  Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
  Renal impairment: 60 mg once daily

• Children 6 months–<2 years:
  Suspension: 15 mg (2.5 ml) twice daily
  Renal impairment: 15 mg (2.5 ml) once daily

Dosage should always be followed as advised by a healthcare professional.

Drug Interactions

Co-administration with erythromycin or ketoconazole may increase fexofenadine plasma levels without clinically significant adverse effects. Antacids containing aluminum or magnesium hydroxide may reduce absorption; a two-hour interval between dosing is recommended.

Contraindications

Contraindicated in patients with known hypersensitivity to fexofenadine or any of the formulation components.

Side Effects

Common side effects include headache, fatigue, dizziness, and nausea, with rates similar to placebo. Rare reactions may include hypersensitivity reactions, palpitations, tachycardia, sleep disturbances, diarrhea, rash, urticaria, and pruritus.

Pregnancy and Lactation

Axodin Oral Suspension is classified as US FDA Pregnancy Category C. Use during pregnancy and breastfeeding is not recommended unless clearly necessary.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Conditions

Store in a cool, dry place away from heat and light. Keep out of reach of children.

Mode of Action

Fexofenadine acts as an inverse agonist at H1 histamine receptors, preventing histamine-mediated allergic responses such as itching, rhinorrhea, and watery eyes. Its inability to cross the blood-brain barrier minimizes central nervous system effects.