Bexitrol F Inhalation Capsule 50 mcg+500 mcg is a fixed-dose combination inhalation therapy containing Salmeterol, a long-acting beta-2 adrenergic agonist, and Fluticasone Propionate, a potent inhaled corticosteroid. This high-strength formulation is intended for the long-term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in patients who require both sustained bronchodilation and strong anti-inflammatory control.

The inhalation capsule is designed to be used with a compatible dry powder inhaler device. It delivers medication directly to the lungs, ensuring targeted action, rapid onset, and minimal systemic exposure. Bexitrol F Inhalation Capsule is not meant for the relief of acute bronchospasm and should be used regularly as prescribed for optimal disease control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Long-acting beta-2 agonist (LABA) + Inhaled corticosteroid (ICS)

Indications

Bexitrol F Inhalation Capsule 50 mcg+500 mcg is indicated for:

• Maintenance treatment of moderate to severe persistent bronchial asthma not adequately controlled with inhaled corticosteroids alone

• Long-term management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema

• Prevention of asthma symptoms such as wheezing, chest tightness, breathlessness, and nocturnal symptoms

This strength is particularly suitable for patients requiring a higher dose of inhaled corticosteroid to achieve adequate symptom control.

Pharmacology

Salmeterol selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, producing prolonged bronchodilation that lasts up to 12 hours. This helps keep the airways open, reduces bronchospasm, and improves airflow throughout the day and night.

Fluticasone Propionate exerts strong anti-inflammatory effects by inhibiting multiple inflammatory pathways. It reduces airway edema, mucus secretion, and inflammatory cell infiltration, thereby decreasing airway hyper-responsiveness and lowering the frequency of asthma exacerbations.

The combination provides complementary and synergistic effects, resulting in improved lung function, better symptom control, and reduced risk of disease flare-ups compared to monotherapy.

Dosage and Administration

Bexitrol F Inhalation Capsule is for inhalation use only.

• The usual recommended dose is one inhalation capsule twice daily or as directed by a physician

• Capsules must not be swallowed and should only be used with a suitable inhaler device

• After inhalation, patients should rinse the mouth with water and spit it out to reduce the risk of oral candidiasis

Regular use is essential to achieve maximum therapeutic benefit.

Contraindications

Bexitrol F Inhalation Capsule is contraindicated in:

• Patients with known hypersensitivity to Salmeterol, Fluticasone Propionate, or any excipients

• Acute asthma attacks or status asthmaticus requiring immediate relief with short-acting bronchodilators

Side Effects

Possible side effects include:

• Throat irritation or hoarseness

• Headache

• Cough

• Oral fungal infections

• Tremor or palpitations (uncommon)

Most side effects are mild and can be minimized with proper inhaler technique and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not intended for emergency relief of acute bronchospasm

• Use with caution in patients with cardiovascular disease, diabetes mellitus, or thyroid disorders

• Avoid abrupt discontinuation without medical advice

• Long-term therapy requires periodic medical evaluation

Pregnancy and Lactation

Bexitrol F Inhalation Capsule should be used during pregnancy and lactation only if the potential benefit justifies the potential risk, and only under medical supervision.

Storage Conditions

Store below 30°C in a cool, dry place. Protect from moisture and direct sunlight. Keep out of reach of children.

Conclusion

Bexitrol F Inhalation Capsule 50 mcg+500 mcg is an effective maintenance therapy for patients with moderate to severe asthma or COPD. By combining long-acting bronchodilation with potent anti-inflammatory action, it supports sustained symptom control, reduces exacerbations, and improves overall respiratory health when used regularly as prescribed.