Calbeta Tablet 5 mg+50 mg is a combination antihypertensive medication containing Amlodipine Besilate 5 mg and Atenolol 50 mg, formulated for the effective management of hypertension and related cardiovascular conditions. This dual-action therapy combines the benefits of a calcium channel blocker and a beta-adrenergic blocker, providing enhanced blood pressure control and reducing the risk of cardiovascular complications such as stroke, heart attack, and heart failure.

Amlodipine works by relaxing blood vessels, thereby reducing peripheral resistance and improving blood flow, while Atenolol slows the heart rate and decreases cardiac workload, contributing to a synergistic antihypertensive effect. Calbeta is particularly useful in patients requiring combination therapy where single-agent treatment is insufficient.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amlodipine Besilate 5 mg – calcium channel blocker

• Atenolol 50 mg – selective beta-1 adrenergic receptor blocker

Mechanism of Action

Amlodipine Besilate:

• Inhibits calcium influx in vascular smooth muscle, leading to vasodilation

• Reduces peripheral vascular resistance, lowering blood pressure

• Improves coronary blood flow, aiding in angina management

Atenolol:

• Selectively blocks beta-1 adrenergic receptors in the heart

• Reduces heart rate, cardiac output, and myocardial oxygen demand

• Helps control arrhythmias and prevent angina attacks

The combination of Amlodipine and Atenolol offers a complementary antihypertensive effect, addressing both vascular resistance and cardiac workload, making it ideal for patients with moderate to severe hypertension.

Indications

Calbeta Tablet 5 mg+50 mg is indicated for:

• Essential hypertension – alone or when monotherapy is insufficient

• Angina pectoris – to prevent chest pain and improve exercise tolerance

• Secondary prevention of cardiovascular events in high-risk patients

• Heart rate control in patients with tachycardia associated with hypertension

• Management of left ventricular dysfunction when clinically appropriate

Benefits

• Effective Blood Pressure Control: Addresses both vascular and cardiac mechanisms

• Reduces Cardiovascular Risk: Lowers the risk of stroke, myocardial infarction, and heart failure

• Dual Mechanism: Amlodipine relaxes vessels, Atenolol decreases heart workload

• Improved Symptom Management: Reduces angina and palpitations in patients with ischemic heart disease

• Convenient Dosing: Once-daily oral tablet promotes adherence

• Suitable for Combination Therapy: Useful for patients unresponsive to single antihypertensive agents

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults: 1 tablet orally once daily, preferably at the same time each day

• Can be taken with or without food

• Dose adjustments may be necessary in elderly patients or those with liver or kidney impairment

• Continuous, daily use is important to maintain stable blood pressure control

• Do not stop therapy abruptly without consulting a physician, as this may cause rebound hypertension or angina exacerbation

Safety and Precautions

• Common side effects: dizziness, headache, fatigue, palpitations, or swelling of the ankles (edema)

• Rare but serious effects: bradycardia, hypotension, heart block, or severe allergic reactions

• Contraindicated in patients with severe bradycardia, uncontrolled heart failure, cardiogenic shock, or hypersensitivity to components

• Use caution in patients with diabetes, asthma, or peripheral vascular disease

• Pregnant or breastfeeding women should consult a healthcare provider before use

• Regular monitoring of blood pressure, heart rate, and kidney function is recommended.