Cortef Injection 100 mg/2 ml contains Hydrocortisone, a fast-acting corticosteroid used to treat a wide range of inflammatory, allergic, autoimmune, and endocrine disorders. It is commonly administered in emergency and hospital settings when rapid corticosteroid therapy is required. Hydrocortisone is a synthetic form of cortisol, a hormone naturally produced by the adrenal glands that plays an essential role in regulating metabolism, immune function, and the body's response to stress.

Cortef Injection is widely used in the management of severe allergic reactions, asthma exacerbations, adrenal crisis, septic shock (in selected patients), and various inflammatory conditions. It helps reduce inflammation, suppress excessive immune responses, and restore adequate corticosteroid levels in patients with adrenal insufficiency. Because of its rapid onset of action, Cortef Injection is often an important part of emergency medical care.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 2 ml injection contains:

• Hydrocortisone 100 mg

Indications

Cortef Injection 100 mg/2 ml is indicated for the treatment of:

• Acute adrenal insufficiency (Addisonian crisis)
• Severe allergic reactions and anaphylaxis (as an adjunct to standard treatment)
• Acute asthma attacks
• Severe inflammatory disorders
• Autoimmune diseases
• Rheumatic disorders
• Dermatological conditions
• Septic shock in selected patients, as recommended by clinical guidelines
• Ulcerative colitis and Crohn's disease during severe flare-ups
• Cerebral edema associated with certain medical conditions, when appropriate
• Other corticosteroid-responsive conditions as determined by a physician

How Cortef Injection Works

Hydrocortisone acts by replacing or supplementing the body's natural cortisol and by suppressing the release of substances that cause inflammation. It also reduces the activity of the immune system when it becomes overactive.

Its therapeutic effects include:

• Reducing inflammation and swelling
• Relieving severe allergic reactions
• Suppressing excessive immune responses
• Restoring corticosteroid levels in adrenal insufficiency
• Stabilizing the body's response during severe illness or stress

These actions help improve symptoms quickly and prevent complications in many acute and chronic medical conditions.

Dosage and Administration

• Cortef Injection should be administered only by a qualified healthcare professional.
• It may be given by intravenous (IV) or intramuscular (IM) injection, depending on the patient's condition and the physician's recommendation.
• The dosage varies according to the patient's age, body weight, severity of illness, and clinical response.
• In emergency situations, higher initial doses may be required, followed by gradual dose adjustment.
• Long-term corticosteroid therapy should never be stopped abruptly; the dose should be reduced gradually under medical supervision.

Benefits of Cortef Injection

Cortef Injection provides several important therapeutic benefits, including:

• Rapid relief from severe inflammation
• Effective treatment of acute allergic reactions
• Life-saving therapy in adrenal crisis
• Helps control asthma exacerbations
• Supports management of autoimmune and inflammatory diseases
• Reduces tissue damage caused by excessive inflammation
• Can be used in emergency and critical care settings
• Helps restore normal corticosteroid levels in patients with adrenal insufficiency

Possible Side Effects

Like all medicines, Cortef Injection may cause side effects, although not everyone experiences them.

Common side effects include:

• Increased blood sugar levels
• Increased appetite
• Fluid retention
• Elevated blood pressure
• Mood changes
• Difficulty sleeping
• Injection site discomfort

Prolonged or high-dose use may increase the risk of:

• Increased susceptibility to infections
• Osteoporosis
• Muscle weakness
• Weight gain
• Stomach ulcers
• Cataracts or glaucoma
• Adrenal suppression

Seek immediate medical attention if you experience severe allergic reactions, persistent fever, black stools, vision changes, or difficulty breathing.

Precautions and Warnings

Before using Cortef Injection, inform your healthcare provider if you:

• Have diabetes
• Have high blood pressure or heart disease
• Have liver or kidney disease
• Have tuberculosis or other infections
• Have osteoporosis
• Have stomach ulcers
• Are pregnant, planning pregnancy, or breastfeeding

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Additional precautions:

• Use only under medical supervision.
• Avoid contact with individuals who have contagious infections if receiving prolonged corticosteroid therapy.
• Regular monitoring of blood pressure, blood glucose, and electrolyte levels may be necessary during treatment.
• Inform your doctor about all medicines you are taking, as Hydrocortisone may interact with several medications.

Storage

• Store below 25°C or according to the manufacturer's instructions.
• Protect from light.
• Do not freeze.
• Keep out of reach of children.
• Use the injection only if the solution is clear and the container is intact.