Covista Tablet combines Sacubitril 24 mg and Valsartan 26 mg to provide effective treatment for heart failure. This combination belongs to a class of medications called ARNI (Angiotensin Receptor-Neprilysin Inhibitors), which work synergistically to reduce strain on the heart, improve cardiac function, and help manage symptoms of heart failure. Sacubitril inhibits neprilysin, leading to increased levels of natriuretic peptides, which help dilate blood vessels and reduce fluid retention. Valsartan blocks angiotensin II receptors, preventing vasoconstriction and lowering blood pressure. Together, they help improve heart efficiency and reduce the risk of hospitalization in patients with chronic heart failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Covista Tablet is indicated for:

• Management of chronic heart failure with reduced ejection fraction (HFrEF)
• Reducing the risk of cardiovascular death and hospitalization due to heart failure
• Patients who remain symptomatic despite standard therapy with ACE inhibitors or other heart failure medications

Mechanism of Action

• Sacubitril: Inhibits neprilysin, increasing levels of beneficial peptides that dilate blood vessels, promote sodium excretion, and reduce fluid overload.
• Valsartan: Blocks angiotensin II from binding to AT1 receptors, preventing vasoconstriction and reducing blood pressure.
• Combined effect: Lowers cardiac workload, reduces fluid retention, improves heart efficiency, and supports long-term heart function.

Dosage and Administration

• The recommended starting dose is one tablet twice daily, or as prescribed by a physician
• Swallow the tablet whole with water
• Can be taken with or without food
• Monitor blood pressure, kidney function, and electrolytes regularly during therapy
• Dose adjustments may be required for patients with renal or hepatic impairment

Benefits

• Improves symptoms of chronic heart failure (fatigue, breathlessness, edema)
• Reduces risk of hospitalization due to heart failure exacerbation
• Supports long-term cardiac function and efficiency
• Combination therapy targets multiple pathways in heart failure for superior efficacy
• Convenient twice-daily oral dosing

Side Effects

Common side effects may include:

• Low blood pressure (hypotension)
• Dizziness or lightheadedness
• Mild cough
• Elevated potassium levels (hyperkalemia)

Rare but serious side effects:

• Kidney dysfunction
• Severe hypotension
• Angioedema (swelling of face, lips, or throat)

Seek immediate medical attention if severe side effects or allergic reactions occur.

Precautions

• Do not take Covista with ACE inhibitors or within 36 hours of an ACE inhibitor dose
• Use with caution in patients with kidney or liver impairment
• Monitor blood pressure and electrolytes regularly
• Inform your doctor if pregnant, planning pregnancy, or breastfeeding
• Avoid abrupt discontinuation of therapy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Contraindicated; may cause fetal harm
• Lactation: Consult a physician before use
• Elderly: Monitor blood pressure and kidney function
• Renal or hepatic impairment: Dose adjustments required

Storage

• Store below 30°C
• Keep in a dry place, protected from light
• Keep out of reach of children.