Dasanix Tablet 50 mg contains Dasatinib, a potent tyrosine kinase inhibitor (TKI) used in the treatment of certain types of leukemia. It is primarily indicated for Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib works by blocking abnormal proteins that promote the growth of cancer cells, thereby slowing or stopping disease progression.

This medication is typically used when patients are resistant or intolerant to prior therapies or as part of first-line treatment in specific cases.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Dasatinib 50 mg

Mechanism of Action

Dasatinib inhibits multiple tyrosine kinases, including BCR-ABL kinase, which is produced by the Philadelphia chromosome abnormality. By blocking this enzyme, Dasatinib prevents the proliferation of leukemic cells. It also inhibits SRC family kinases and other signaling pathways involved in cancer cell growth and survival.

Indications

Dasanix Tablet 50 mg is indicated for:

• Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic, accelerated, or blast phase
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
• Patients resistant or intolerant to prior therapies such as imatinib
• First-line therapy in selected CML patients as per oncologist recommendation

Dosage and Administration

• To be taken orally as prescribed by a qualified healthcare professional
• Can be taken with or without food
• Tablets should be swallowed whole without crushing or breaking
• Dosage varies depending on disease phase and patient condition
• Regular monitoring of blood counts and clinical response is essential

Contraindications

Dasanix Tablet should not be used in:

• Known hypersensitivity to Dasatinib
• Severe hepatic impairment without medical supervision
• Pregnancy and breastfeeding unless clearly advised by a specialist

Side Effects

Common and serious side effects may include:

• Bone marrow suppression (anemia, neutropenia, thrombocytopenia)
• Fluid retention (pleural effusion, edema)
• Diarrhea
• Headache
• Fatigue
• Skin rash
• Bleeding events
• QT prolongation (cardiac rhythm disturbance)

Precautions

• Regular monitoring of blood counts is essential
• Monitor for signs of fluid retention and respiratory symptoms
• Use cautiously in patients with liver disease or heart conditions
• Electrolyte levels should be monitored
• Avoid use of drugs that prolong QT interval without medical advice
• Should be used only under oncologist supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Dasanix Tablet may interact with:

• Strong CYP3A4 inhibitors or inducers
• Antacids and proton pump inhibitors (may reduce absorption)
• Anticoagulants (increased bleeding risk)
• Drugs affecting cardiac rhythm

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.