Denomab Injection 60 mg/ml contains Denosumab, a targeted biological therapy used to strengthen bones and reduce the risk of fractures. It works by inhibiting a key pathway involved in bone breakdown, making it an important treatment for patients with osteoporosis and other bone-related disorders.

Denomab is administered as a subcutaneous injection under medical supervision and is typically given at scheduled intervals for long-term bone protection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each ml contains:

• Denosumab 60 mg

It is intended for subcutaneous (SC) injection only.

Mechanism of Action

Denosumab works by targeting the RANK/RANKL pathway:

• Binds to and inhibits RANK ligand (RANKL)
• Prevents activation of osteoclasts (cells responsible for bone resorption)
• Reduces bone breakdown
• Increases bone mineral density
• Strengthens bone structure and reduces fracture risk

This mechanism helps maintain bone strength and prevents excessive bone loss.

Indications

Denomab Injection is indicated for:

• Osteoporosis
• Postmenopausal women with high risk of fractures
• Patients with bone loss due to long-term steroid use
• Men with osteoporosis at increased fracture risk

Dosage and Administration

• Administered as a subcutaneous injection every 6 months (as prescribed)
• Given by a healthcare professional
• Injection sites commonly include upper arm, thigh, or abdomen
• Calcium and vitamin D supplementation is often recommended during therapy

Regular follow-up is necessary to monitor bone health and calcium levels.

Benefits

Denomab Injection provides several benefits:

• Increases bone strength and density
• Reduces risk of spine and hip fractures
• Long-lasting effect with infrequent dosing
• Effective in postmenopausal osteoporosis
• Improves overall skeletal health

Possible Side Effects

Common side effects include:

• Back pain
• Muscle or joint pain
• Mild skin reactions at injection site
• Headache

Less common but serious side effects:

• Low calcium levels (hypocalcemia)
• Serious infections (rare)
• Jaw bone problems (osteonecrosis of the jaw)
• Unusual thigh bone fractures (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Ensure adequate calcium and vitamin D intake before and during treatment
• Regular monitoring of calcium levels is recommended
• Use cautiously in patients with kidney disease
• Inform dentist before dental procedures
• Not recommended during pregnancy

Storage

Store in a refrigerator at 2–8°C, do not freeze. Protect from light and keep out of reach of children.