Diasulin Injection 50%+50% combines Regular Insulin Human and Isophane Insulin Human (NPH) in a 50:50 ratio, formulated at 100 IU/ml. This premixed insulin is designed for patients with type 1 and type 2 diabetes mellitus who require both rapid-acting and intermediate-acting insulin to achieve optimal blood glucose control. The combination provides immediate glucose-lowering action with sustained effects, helping manage fasting and postprandial blood sugar levels effectively.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regular Insulin Human 50% (rapid-acting)
• Isophane Insulin Human 50% (intermediate-acting)
• Strength: 100 IU/ml

Indications

Diasulin Injection is indicated for:

• Type 1 diabetes mellitus requiring insulin therapy
• Type 2 diabetes mellitus when oral antidiabetic drugs are insufficient
• Management of hyperglycemia in hospitalized patients or those with fluctuating glucose levels
• Situations requiring both rapid and intermediate blood glucose control

Mechanism of Action

• Regular Insulin Human: Rapid-acting insulin that lowers blood glucose by promoting cellular uptake of glucose, inhibiting hepatic glucose production, and enhancing protein and lipid metabolism.
• Isophane Insulin Human (NPH): Intermediate-acting insulin providing prolonged glucose control by slowly releasing insulin over 12–16 hours.

The combination ensures rapid onset to control postprandial spikes and extended action for basal glucose management.

Dosage and Administration

• Administer subcutaneously as prescribed by a healthcare professional
• Dosage individualized based on blood glucose monitoring, diet, and lifestyle
• Commonly injected before meals to optimize postprandial glucose control
• Do not mix with other insulins unless recommended by a physician
• Rotate injection sites to prevent lipodystrophy

Benefits

• Convenient premixed formulation combining rapid and intermediate action
• Reduces the need for multiple injections daily
• Effective control of both fasting and post-meal blood glucose
• Supports better glycemic stability and reduces risk of hyperglycemia
• Flexible dosing to suit individual patient needs

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Injection site reactions such as redness, swelling, or itching
• Mild weight gain

Rare side effects:

• Severe allergic reactions (rash, difficulty breathing, swelling)
• Lipodystrophy at repeated injection sites

Seek medical attention immediately if severe hypoglycemia or allergic reactions occur.

Precautions

• Monitor blood glucose regularly to prevent hypoglycemia or hyperglycemia
• Adjust dosage during illness, stress, or changes in diet or activity
• Use cautiously in patients with kidney, liver, or cardiovascular disease
• Carry a source of fast-acting sugar to treat hypoglycemia

Contraindications

• Hypersensitivity to insulin or any component of the formulation
• Severe hypoglycemia

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral antidiabetic agents, beta-blockers, corticosteroids, diuretics, and other medications affecting blood glucose
• Inform your healthcare provider about all medications currently being taken

Storage

• Store refrigerated at 2–8°C; do not freeze
• Keep away from direct heat and light
• Once opened, in-use vials can be stored at room temperature (below 30°C) for up to 28 days
• Keep out of reach of children.