Dinovo Tablet 375 mg + 20 mg is a fixed-dose combination of Naproxen Sodium (375 mg) and Esomeprazole Magnesium (20 mg), developed to provide effective relief from pain and inflammation while minimizing gastrointestinal side effects commonly associated with nonsteroidal anti-inflammatory drugs (NSAIDs). This formulation is especially beneficial for patients who need long-term NSAID therapy and are at increased risk of acid-related gastric discomfort or ulceration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Naproxen Sodium 375 mg

• Esomeprazole Magnesium 20 mg

Therapeutic Class

Nonsteroidal Anti-inflammatory Drug (NSAID)
Proton Pump Inhibitor (PPI)

Pharmacology

Naproxen Sodium exerts its analgesic and anti-inflammatory effects by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), leading to reduced prostaglandin synthesis. This results in effective relief from pain, swelling, stiffness, and inflammation in acute and chronic conditions.

Esomeprazole Magnesium is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme in gastric parietal cells. By lowering gastric acid levels, esomeprazole protects the stomach lining and reduces the risk of NSAID-induced gastric erosion, ulceration, and dyspepsia.

The combined formulation ensures sustained pain control while enhancing gastrointestinal safety, making it suitable for prolonged use under medical supervision.

Indications

Dinovo Tablet 375 mg + 20 mg is indicated for the management of:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic joint and musculoskeletal pain

• Acute inflammatory conditions

• Patients requiring NSAID therapy with increased risk of gastric irritation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• The usual recommended dose is one tablet once or twice daily, depending on the severity of symptoms and physician advice.

• The tablet should be swallowed whole with sufficient water and should not be crushed or chewed.

• It is preferably taken before meals to allow optimal acid suppression.

Dose and duration should be determined by a healthcare professional based on individual patient needs.

Contraindications

Dinovo Tablet is contraindicated in patients with:

• Hypersensitivity to naproxen, esomeprazole, or other NSAIDs

• Active peptic ulcer disease or gastrointestinal bleeding

• Severe renal or hepatic impairment

• History of NSAID-induced bronchospasm or allergic reactions

• Pregnancy, particularly during the third trimester

Precautions and Warnings

• Long-term NSAID use may increase the risk of cardiovascular events; use the lowest effective dose.

• Caution is advised in elderly patients and those with a history of gastrointestinal disorders.

• Renal and hepatic function should be monitored during prolonged therapy.

• Avoid concomitant use with other NSAIDs unless prescribed.

Side Effects

Possible side effects may include:

• Nausea, abdominal discomfort, or indigestion

• Headache or dizziness

• Diarrhea or constipation

• Peripheral edema with long-term use

Most adverse effects are mild and reversible.

Use in Special Populations

• Pregnancy: Not recommended, especially in late pregnancy.

• Lactation: Use with caution and under medical supervision.

• Elderly: Close monitoring is recommended due to higher susceptibility to side effects.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.