Dirozyl Injection 500 mg/100 ml contains Metronidazole, a potent nitroimidazole antibiotic with broad-spectrum activity against anaerobic bacteria and certain protozoa. This intravenous formulation is designed for parenteral administration, making it suitable for patients who cannot take oral medications or require rapid systemic treatment. Dirozyl Injection is commonly used in hospital and clinical settings for severe infections, complicated bacterial conditions, and protozoal diseases.

Metronidazole works by disrupting DNA synthesis in susceptible microorganisms, leading to cell death. It is particularly effective against Bacteroides species, Clostridium species, and Trichomonas vaginalis, among others. This makes it an essential therapeutic option for managing serious anaerobic infections, intra-abdominal infections, gynecological infections, and protozoal diseases.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Metronidazole: 500 mg per 100 ml

Indications

Dirozyl Injection 500 mg/100 ml is indicated for:

• Anaerobic bacterial infections, including intra-abdominal infections

• Bacterial vaginosis and gynecological infections

• Trichomoniasis and other protozoal infections

• Severe skin and soft tissue infections

• Septicemia caused by susceptible anaerobes

• Adjunct therapy for surgical prophylaxis in high-risk patients

• Treatment of complicated infections in patients unable to take oral therapy

Mechanism of Action

Metronidazole exerts its antimicrobial effect by penetrating bacterial and protozoal cells and interacting with their DNA. Once inside the cell, it undergoes reduction of its nitro group, producing reactive intermediates that bind to DNA and inhibit nucleic acid synthesis. This process results in the destruction of the microorganism, making Metronidazole bactericidal against anaerobic bacteria and protozoa. Its selective activity against anaerobes and certain protozoa ensures minimal impact on normal aerobic flora.

Dosage and Administration

• Route: Intravenous infusion

• Dosage: As prescribed by a registered physician

The dose depends on the type, severity, and location of infection, as well as patient age, weight, and renal/hepatic function. Dirozyl Injection should be administered slowly via IV infusion over 30–60 minutes, under close medical supervision to ensure safety and effectiveness.

Benefits of Dirozyl Injection 500 mg/100 ml

• Rapid and effective treatment for severe infections

• Broad-spectrum activity against anaerobic bacteria and protozoa

• Suitable for patients unable to take oral antibiotics

• Can be used in combination therapy for complicated infections

• Supports faster recovery in systemic or hospital-acquired infections

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision

• Caution in patients with hepatic or renal impairment

• Monitor for neurological side effects such as seizures or neuropathy with prolonged therapy

• May interact with alcohol, causing disulfiram-like reactions

• Not recommended during the first trimester of pregnancy unless clearly indicated

Storage Conditions

• Store below 30°C

• Protect from light

• Keep out of reach of children

• Do not freeze

Pharmaceutical Category

Nitroimidazole Antibiotic.