Dolceta Tablet 325 mg + 37.5 mg is a combination analgesic containing Paracetamol 325 mg and Tramadol Hydrochloride 37.5 mg, formulated for the effective management of moderate to moderately severe pain. This dual-action medication provides both central and peripheral pain relief, offering enhanced analgesic effectiveness compared to single-agent therapy.

Paracetamol (Acetaminophen) is a widely used analgesic and antipyretic that works primarily in the central nervous system to reduce pain and fever. Tramadol Hydrochloride is a centrally acting opioid analgesic that binds to opioid receptors and also inhibits the reuptake of norepinephrine and serotonin, contributing to pain relief through multiple pathways.

The synergistic combination in Dolceta allows for effective pain control at lower opioid doses, potentially reducing opioid-related side effects while maintaining strong analgesic action. It is commonly prescribed for postoperative pain, musculoskeletal pain, dental pain, injury-related pain, and other acute painful conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Opioid and Non-Opioid Combination Analgesic

• Centrally Acting Pain Reliever

Composition

Each tablet contains:

• Paracetamol: 325 mg

• Tramadol Hydrochloride: 37.5 mg

This balanced formulation provides effective pain management while minimizing excessive opioid exposure.

Indications

Dolceta Tablet is indicated for:

• Management of moderate to moderately severe pain

• Postoperative pain relief

• Musculoskeletal pain

• Acute injury-related pain

• Dental pain

• Pain not adequately controlled by non-opioid analgesics alone

It is intended for short-term use under medical supervision.

Mechanism of Action

Paracetamol:

• Inhibits prostaglandin synthesis in the central nervous system

• Provides analgesic and antipyretic effects

Tramadol Hydrochloride:

• Binds to mu-opioid receptors in the brain

• Inhibits reuptake of serotonin and norepinephrine

• Enhances descending inhibitory pain pathways

The combination provides multimodal pain relief through complementary mechanisms.

Dosage and Administration

• Usually 1–2 tablets every 4–6 hours, as prescribed

• Do not exceed the maximum recommended daily dose

• Swallow whole with water; do not crush or chew

• Use the lowest effective dose for the shortest duration necessary

• Avoid alcohol during treatment

Dosage adjustments may be required in elderly patients or those with renal or hepatic impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Nausea and vomiting

• Dizziness or drowsiness

• Constipation

• Headache

Serious side effects may include respiratory depression, allergic reactions, seizures (rare), or signs of liver toxicity. Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Risk of dependence and misuse due to Tramadol content

• Avoid in patients with severe respiratory depression or uncontrolled epilepsy

• Use cautiously in hepatic or renal impairment

• Not recommended during pregnancy or breastfeeding unless prescribed

• Do not combine with other paracetamol-containing products to avoid overdose

Storage

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children.