Dolonil Capsule 50 mg contains Tramadol Hydrochloride, a centrally acting analgesic designed for the management of moderate to moderately severe pain. This oral formulation provides convenient, effective pain relief for patients who require consistent dosing over a longer period. It is suitable for conditions such as post-operative pain, musculoskeletal pain, neuropathic pain, and other acute or chronic pain disorders.

Tramadol combines opioid receptor agonism with inhibition of norepinephrine and serotonin reuptake, offering a unique dual mechanism that enhances analgesic efficacy while reducing the potential side effects associated with stronger opioids. Dolonil Capsule 50 mg is widely used for its effectiveness, ease of administration, and predictable pharmacological profile.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tramadol Hydrochloride: 50 mg per capsule

Indications

Dolonil Capsule 50 mg is indicated for:

• Relief of moderate to moderately severe pain

• Post-operative pain management

• Pain due to musculoskeletal disorders such as arthritis, sprains, or back pain

• Neuropathic pain, including diabetic neuropathy

• Acute pain episodes following injury or trauma

• Situations where oral analgesics are preferred over injections

Mechanism of Action

Tramadol hydrochloride acts via a dual mechanism to alleviate pain:

1. Opioid receptor activation: It binds to μ-opioid receptors in the central nervous system, reducing the perception of pain.

2. Monoamine reuptake inhibition: Tramadol inhibits the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways in the spinal cord.

This combination provides effective analgesia with a lower risk of respiratory depression compared to stronger opioids when used appropriately. The dual action also makes it effective for certain neuropathic pain conditions.

Dosage and Administration

• Route: Oral

• Dosage: As prescribed by a registered physician

The usual adult dose is one capsule every 4–6 hours as needed, not exceeding the maximum recommended daily dose. Capsules should be swallowed whole with water and can be taken with or without food. Dosage adjustments may be necessary for elderly patients or those with renal or hepatic impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits of Dolonil Capsule 50 mg

• Effective relief from moderate to moderately severe pain

• Convenient oral administration for home or outpatient use

• Dual mechanism provides enhanced analgesic efficacy

• Predictable and reliable pain control

• Can be integrated into long-term pain management plans under medical supervision

Precautions and Warnings

• Use only under medical supervision

• Not recommended for patients with hypersensitivity to tramadol or opioids

• Caution in patients with respiratory disorders, epilepsy, liver or kidney impairment, or history of substance abuse

• Avoid alcohol or CNS depressants during therapy

• Monitor for side effects such as nausea, dizziness, constipation, or drowsiness

• Not suitable for pediatric patients unless specifically prescribed

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Pharmaceutical Category

Opioid Analgesic.