Dopair Tablet combines Levodopa 50 mg with Carbidopa 12.5 mg, a standard therapy for managing Parkinson’s disease and parkinsonian syndromes. Levodopa replenishes dopamine levels in the brain, improving motor function and alleviating symptoms such as tremors, rigidity, and slowness of movement. Carbidopa inhibits the peripheral metabolism of Levodopa, allowing more to reach the brain and reducing side effects like nausea and vomiting. This lower-dose formulation is ideal for initial therapy or for patients requiring gradual dose titration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Levodopa 50 mg (dopamine precursor)
• Carbidopa 12.5 mg (peripheral dopa-decarboxylase inhibitor)

Indications

Dopair Tablet is indicated for:

• Parkinson’s disease (all stages)
• Parkinsonian syndromes caused by dopamine deficiency
• Relief of motor symptoms including tremor, rigidity, and bradykinesia

Mechanism of Action

• Levodopa: Crosses the blood-brain barrier and is converted into dopamine, replenishing deficient levels in the central nervous system.
• Carbidopa: Inhibits peripheral conversion of Levodopa to dopamine, increasing central availability and minimizing gastrointestinal and cardiovascular side effects.

The combination ensures effective symptom control with better tolerability.

Dosage and Administration

• Take orally as prescribed by a healthcare professional
• Typically administered 1–3 times daily depending on symptom severity and patient response
• Can be taken with or after meals to reduce gastrointestinal discomfort
• Dosage should be adjusted gradually, especially in initial therapy

Benefits

• Improves motor function and mobility in Parkinson’s patients
• Reduces tremors, rigidity, and slow movements
• Minimizes nausea and peripheral side effects due to Carbidopa
• Suitable for initial therapy or gradual dose titration
• Supports better quality of life and daily functioning

Side Effects

Common side effects:

• Nausea and vomiting
• Dizziness or lightheadedness
• Dyskinesia (involuntary movements)
• Orthostatic hypotension

Rare side effects:

• Hallucinations or confusion
• Cardiac arrhythmias
• Severe allergic reactions

Seek medical attention if severe or persistent side effects occur.

Precautions

• Monitor blood pressure regularly, particularly in elderly patients
• Use with caution in patients with heart disease, psychiatric disorders, or liver/kidney impairment
• Avoid abrupt discontinuation; adjust dosage only under medical supervision
• Inform your doctor about all other medications, especially MAO inhibitors and antihypertensives

Contraindications

• Hypersensitivity to Levodopa, Carbidopa, or any component of the formulation
• Narrow-angle glaucoma
• History of melanoma or suspicious skin lesions
• Concurrent use of non-selective MAO inhibitors

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with MAO inhibitors, antipsychotics, antihypertensives, and iron supplements
• Always inform your healthcare provider of all medications being used

Storage

• Store in a cool, dry place below 30°C
• Protect from light and moisture
• Keep out of reach of children.