Duphaston Tablet 10 mg contains Dydrogesterone 10 mg, a synthetic progesterone hormone used to treat a variety of menstrual and reproductive disorders. Dydrogesterone mimics the action of natural progesterone, helping to regulate the menstrual cycle, support early pregnancy, and correct hormonal imbalances.

Progesterone plays a vital role in maintaining the uterine lining (endometrium), which is essential for successful implantation and pregnancy. Duphaston is commonly prescribed for women experiencing menstrual irregularities, luteal phase defects, endometriosis, or recurrent pregnancy loss due to progesterone deficiency. It helps restore hormonal balance, promotes regular menstruation, and supports healthy pregnancy outcomes.

This oral tablet offers convenient, controlled dosing, making it suitable for long-term therapy under medical supervision. Duphaston does not exhibit androgenic, estrogenic, or glucocorticoid activity, minimizing the risk of unwanted hormonal side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Duphaston Tablet 10 mg is indicated for:

• Menstrual disorders including irregular cycles, painful periods (dysmenorrhea), and premenstrual syndrome

• Progesterone deficiency, such as luteal phase defects causing infertility

• Endometriosis, to reduce pelvic pain and lesion growth

• Threatened or recurrent miscarriage due to insufficient progesterone

• Hormone replacement therapy in combination with estrogen for women with menopause-related symptoms

Key Benefits

• Regulates menstrual cycles and alleviates menstrual discomfort

• Supports uterine lining development for successful implantation and pregnancy

• Reduces pain and symptoms of endometriosis

• Safe for long-term therapy with minimal hormonal side effects

• Improves fertility outcomes in women with progesterone-related reproductive issues

Mechanism of Action

Dydrogesterone, the active ingredient in Duphaston, is a synthetic progestogen that binds selectively to progesterone receptors in the endometrium.

• Endometrial support: Promotes development of a receptive endometrium for implantation of a fertilized ovum.

• Hormonal balance: Counteracts estrogen dominance, preventing abnormal endometrial proliferation and menstrual irregularities.

• Pregnancy support: Maintains the uterine lining during early pregnancy, reducing the risk of miscarriage due to progesterone deficiency.

Unlike natural progesterone, dydrogesterone has high oral bioavailability and minimal androgenic or estrogenic effects, making it safer and more predictable in therapeutic use.

Dosage and Administration

• Dosage varies depending on the condition and stage of treatment; typically:

  • Menstrual disorders: 10 mg daily from day 16 to day 25 of the menstrual cycle

  • Infertility or luteal phase support: 10 mg daily, starting after ovulation for 10–14 days

  • Threatened miscarriage: Dose and duration as prescribed by a physician

• Tablets should be taken orally with water, preferably at the same time each day.

• Therapy should always be guided by a physician to optimize outcomes.

Precautions

• Use cautiously in patients with liver dysfunction, thromboembolic disorders, or hormone-sensitive cancers.

• Inform the physician about all medications to avoid potential interactions.

• Not recommended for use during undiagnosed vaginal bleeding.

• Regular monitoring may be required in long-term therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Duphaston Tablet 10 mg is generally well tolerated. Side effects may include:

• Headache or migraine

• Nausea or gastrointestinal discomfort

• Breast tenderness or bloating

• Rarely, mood changes or mild dizziness

Most side effects are mild and transient, resolving with continued use.

Storage

Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.