Exovate N Ointment is a potent triple-combination topical preparation containing Clobetasol Propionate, Neomycin Sulphate, and Nystatin. It is specially formulated for the treatment of severe inflammatory skin disorders associated with secondary bacterial and fungal infections. The ointment base provides enhanced occlusion and penetration, making it particularly suitable for dry, thickened, and chronic skin lesions where intensive therapy is required.

This combination delivers rapid symptomatic relief from redness, swelling, itching, and discomfort while simultaneously eliminating susceptible bacteria and fungi. Exovate N Ointment is intended for short-term use under medical supervision due to the presence of a super-potent corticosteroid.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition and Therapeutic Class

Each gram contains:

• Clobetasol Propionate 0.5 mg

• Neomycin Sulphate 5 mg

• Nystatin 1 Lac IU

Therapeutic Class:
Topical corticosteroid with antibacterial and antifungal agents

Indications

Exovate N Ointment is indicated for the treatment of steroid-responsive dermatoses where inflammation is complicated by bacterial and/or fungal infection, including:

• Infected eczema

• Severe inflammatory dermatitis

• Chronic skin conditions with secondary infection

• Fungal infections accompanied by marked inflammation

• Mixed dermal infections requiring combined therapy

The ointment formulation is especially beneficial for dry, scaly, or lichenified lesions.

Pharmacology

Clobetasol Propionate is a super-high potency topical corticosteroid that exerts strong anti-inflammatory, antipruritic, and vasoconstrictive effects. It reduces inflammation by suppressing the release of inflammatory mediators, inhibiting immune cell activity, and decreasing capillary permeability, resulting in rapid control of erythema, edema, and itching.

Neomycin Sulphate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is effective against a wide range of Gram-positive and Gram-negative organisms commonly involved in secondary skin infections.

Nystatin is a polyene antifungal agent that acts by binding to sterols in fungal cell membranes, causing leakage of intracellular contents and cell death. It is particularly active against Candida species.

The combined pharmacological action ensures comprehensive management of inflammation while addressing underlying bacterial and fungal pathogens.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Apply a thin layer of Exovate N Ointment to the affected area once or twice daily

• Massage gently until absorbed

• Use for the shortest effective duration as advised by a physician

• Do not use under occlusive dressings unless specifically instructed

Contraindications

Exovate N Ointment is contraindicated in patients with:

• Hypersensitivity to Clobetasol Propionate, Neomycin, Nystatin, or any excipient

• Viral skin infections such as herpes simplex or varicella

• Acne vulgaris

• Rosacea

• Perioral dermatitis

• Untreated primary skin infections

Side Effects

When used as prescribed, Exovate N Ointment is generally well tolerated. Possible adverse effects include:

• Burning or stinging sensation

• Skin irritation or dryness

• Folliculitis

• Skin thinning, striae, or telangiectasia with prolonged use

Excessive or long-term application may increase the risk of systemic corticosteroid absorption.

Use in Pregnancy and Lactation

Safety data during pregnancy and lactation are limited. Exovate N Ointment should be used only when clearly needed and under medical supervision. Prolonged or extensive use should be avoided.

Precautions and Warnings

• For external use only

• Avoid contact with eyes and mucous membranes

• Do not apply on large body surfaces or broken skin without medical advice

• Use with caution in children due to increased risk of systemic absorption

• Discontinue if signs of irritation or hypersensitivity occur

Storage Conditions

Store below 30°C, protected from heat and light. Keep out of reach of children.