Fenazine Injection 25 mg/ml contains Fluphenazine Decanoate, a long-acting antipsychotic medication belonging to the phenothiazine class. It is formulated as a depot injection designed for intramuscular administration, providing sustained therapeutic effects over an extended period. Fenazine Injection is primarily used in the long-term management of chronic psychotic disorders, particularly schizophrenia, in patients who require continuous antipsychotic treatment and may have difficulty adhering to oral medication regimens.

The depot formulation ensures steady plasma drug levels, reducing symptom relapse associated with inconsistent dosing and improving overall treatment compliance. Fenazine Injection is intended for use under strict medical supervision by trained healthcare professionals.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Typical Antipsychotic / Phenothiazine Derivative

Indications

Fenazine Injection 25 mg/ml is indicated for:

• Maintenance treatment of schizophrenia

• Long-term management of chronic psychotic disorders

• Patients requiring prolonged antipsychotic therapy where oral treatment adherence is inadequate

Composition

Each ml contains:

• Fluphenazine Decanoate BP 25 mg

Pharmacology

Fluphenazine Decanoate is a long-acting ester of fluphenazine, a potent dopamine D2 receptor antagonist. After intramuscular injection, the decanoate ester is slowly hydrolyzed to release active fluphenazine into the systemic circulation. By blocking dopamine receptors in the mesolimbic and mesocortical pathways, it helps control positive symptoms of psychosis such as hallucinations, delusions, and disorganized thinking. The depot formulation allows sustained antipsychotic activity for several weeks following a single injection.

Mode of Action

Fenazine Injection exerts its antipsychotic effect by antagonizing dopamine D2 receptors in the brain. This action reduces excessive dopaminergic activity associated with psychotic symptoms. Its long-acting nature ensures stable drug levels, minimizing symptom fluctuations and reducing the risk of relapse.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage & Administration

• Administered by deep intramuscular injection only

• Initial and maintenance doses are individualized based on patient response and clinical condition

• Common dosing interval ranges from every 2 to 4 weeks

• Dose adjustment should be done gradually under medical supervision

Drug Interactions

Fenazine Injection may interact with:

• Central nervous system depressants such as alcohol, sedatives, and opioids

• Antihypertensive drugs, which may enhance hypotensive effects

• Anticholinergic agents and other antipsychotics

Concomitant use should be monitored carefully by a healthcare professional.

Contraindications

Fenazine Injection is contraindicated in patients with:

• Hypersensitivity to fluphenazine or other phenothiazines

• Severe central nervous system depression

• Comatose states

• Bone marrow depression

Side Effects

Possible side effects include:

• Extrapyramidal symptoms such as rigidity, tremor, and akathisia

• Sedation and dizziness

• Orthostatic hypotension

• Dry mouth, constipation, and blurred vision

• Injection site reactions

Long-term use may be associated with tardive dyskinesia.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fluphenazine may be excreted in breast milk; therefore, breastfeeding is not recommended during treatment.

Precautions & Warnings

Regular monitoring is advised for patients receiving long-term therapy. Caution should be exercised in elderly patients and those with cardiovascular disease, hepatic impairment, or seizure disorders.

Storage Conditions

Store below 30°C, protected from light. Keep out of the reach of children.