Fixocard Tablet 5 mg + 25 mg is a fixed-dose combination antihypertensive medication containing Amlodipine Besilate (5 mg) and Atenolol (25 mg). This combination is specifically formulated to provide effective control of high blood pressure (hypertension) and to reduce cardiovascular risk by targeting blood pressure through two complementary mechanisms. Fixocard is suitable for patients who require combination therapy when single-drug treatment is insufficient to achieve optimal blood pressure control.

Amlodipine is a long-acting calcium channel blocker, while Atenolol is a cardioselective beta-1 adrenergic receptor blocker. Together, they work synergistically to lower blood pressure, reduce cardiac workload, and improve overall cardiovascular outcomes. Fixocard Tablet is generally well tolerated and is intended for long-term management of hypertension and related cardiovascular conditions under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Fixocard Tablet 5 mg + 25 mg is indicated for:

• Management of essential hypertension

• Treatment of hypertension associated with stable angina pectoris

• Reduction of cardiovascular risk in patients requiring combination antihypertensive therapy

• Patients inadequately controlled with monotherapy of either a calcium channel blocker or a beta-blocker

Therapeutic Class

Combination of:

• Calcium Channel Blocker

• Beta-Adrenergic Blocker

Pharmacology

Amlodipine Besilate inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. This leads to peripheral arterial vasodilation, resulting in reduced systemic vascular resistance and lowered blood pressure. Its gradual onset and long duration of action help maintain stable blood pressure control over 24 hours.

Atenolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output. This action decreases myocardial oxygen demand and contributes to blood pressure reduction without significant effects on beta-2 receptors in the lungs at therapeutic doses.

The combination provides additive antihypertensive effects while minimizing dose-related side effects of individual agents.

Dosage & Administration

• The usual recommended dose is one tablet once daily, or as directed by the registered physician.

• Fixocard Tablet may be taken with or without food.

• The tablet should be swallowed whole with water at the same time each day to maintain consistent blood levels.

• Dosage adjustments should be made based on patient response and tolerability.

Drug Interactions

Fixocard Tablet should be used with caution when taken with:

• Other antihypertensive agents, due to additive blood pressure-lowering effects

• Antiarrhythmic drugs, digoxin, or calcium channel blockers affecting cardiac conduction

• Nonsteroidal anti-inflammatory drugs, which may reduce antihypertensive efficacy

• Antidiabetic medications, as beta-blockers may mask symptoms of hypoglycemia

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Fixocard Tablet is contraindicated in patients with:

• Known hypersensitivity to amlodipine, atenolol, or any excipients

• Severe bradycardia, heart block greater than first degree, or cardiogenic shock

• Uncontrolled heart failure

• Severe hypotension

Side Effects

Common side effects may include:

• Dizziness, headache, or fatigue

• Peripheral edema, flushing, or palpitations

• Bradycardia and cold extremities

Less common effects include gastrointestinal disturbances, sleep disturbances, and mood changes. Most side effects are mild and transient with continued use.

Pregnancy & Lactation

Fixocard Tablet should be used during pregnancy only if the potential benefit justifies the possible risk to the fetus. Caution is advised during breastfeeding, as atenolol is excreted in breast milk. Use only under medical supervision.

Precautions & Warnings

• Use with caution in patients with diabetes, renal impairment, or peripheral vascular disease

• Beta-blockers should not be withdrawn abruptly, as this may worsen angina or hypertension

• Regular monitoring of blood pressure and heart rate is recommended

Storage Conditions

Store below 30°C in a dry place, protected from light and moisture. Keep out of the reach of children.