Flexor 5 mg contains Cyclobenzaprine, a centrally acting skeletal muscle relaxant. It is primarily used as an adjunct to rest and physical therapy for the relief of muscle spasm associated with acute, painful musculoskeletal conditions. The therapeutic benefit of Flexor 5 mg is observed through reduced muscle spasm and improvement in related symptoms such as pain, tenderness, restricted movement, and limitations in daily activities.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Flexor 5 mg is indicated for:

• Relief of muscle spasm associated with acute, painful musculoskeletal conditions

• Improvement of pain, muscle tenderness, and stiffness

• Enhancement of mobility and daily functional activities when used alongside rest and physical therapy

Therapeutic Class

Locally Acting Skeletal Muscle Relaxants

Pharmacology

Cyclobenzaprine is a centrally acting skeletal muscle relaxant that is structurally related to tricyclic antidepressants and shares some of their pharmacological properties. It exerts its effect mainly at the brain stem by reducing tonic somatic motor activity, influencing both alpha (α) and gamma (γ) motor neurons. This action leads to decreased muscle hyperactivity and relief from muscle spasm without directly affecting neuromuscular transmission or muscle function.

Dosage and Administration

• Adults: 5 mg three times daily. The dose may be increased to 10 mg three times daily if required.

• Maximum Dose: 60 mg per day

• Duration of Therapy: Treatment should not exceed 2–3 weeks

• Elderly: Initiate therapy with 5 mg at a reduced dosing frequency

• Pediatric: Safety and effectiveness in children below 15 years of age have not been established

Drug Interactions

Plasma concentration of cyclobenzaprine may be increased when used with cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, or verapamil. Central nervous system effects may be enhanced when taken with other CNS depressants such as sedatives, anxiolytics, opioids, antihistamines, antipsychotics, or alcohol. Concomitant use with MAO inhibitors, certain antiarrhythmics, or serotonergic agents may increase the risk of adverse reactions. Caution is advised with drugs that alter hepatic metabolism, such as carbamazepine or rifampicin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Flexor 5 mg is contraindicated in patients with:

• Recent myocardial infarction

• Cardiac arrhythmias

• Severe hepatic impairment

Side Effects

The most commonly reported adverse effects include:

• Drowsiness

• Dry mouth

• Dizziness
  These effects are generally mild to moderate and may decrease with continued use.

Pregnancy and Lactation

Flexor 5 mg is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed. Caution is advised when administering to breastfeeding mothers.

Precautions and Warnings

Due to its anticholinergic properties, Flexor 5 mg should be used cautiously in patients with urinary retention, angle-closure glaucoma, increased intraocular pressure, or those receiving anticholinergic medications.

Use in Special Populations

In patients with mild hepatic impairment, therapy should begin at 5 mg with slow dose titration. Use in moderate to severe hepatic impairment is not recommended.