Flutisal Inhalation Capsule 50 mcg + 500 mcg is a combination respiratory therapy containing Salmeterol and Fluticasone Propionate. This dual-action medication is formulated for inhalation and designed for the long-term management of moderate to severe asthma and chronic obstructive pulmonary disease (COPD). By combining a long-acting bronchodilator with a potent inhaled corticosteroid, Flutisal helps improve breathing, reduce inflammation, and prevent exacerbations, offering patients better control over their respiratory conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Flutisal Inhalation Capsule 50 mcg + 500 mcg is indicated for:

• Maintenance treatment of moderate to severe asthma in patients who require both a long-acting beta₂-agonist and an inhaled corticosteroid

• Long-term management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema

• Prevention of asthma-related symptoms such as wheezing, breathlessness, chest tightness, and coughing

This combination therapy is not intended for the relief of acute asthma attacks.

Therapeutic Class

Long-acting Beta₂-Agonist and Inhaled Corticosteroid Combination

Pharmacology

Flutisal combines the complementary mechanisms of two active agents:

• Salmeterol (50 mcg): A long-acting selective beta₂-adrenergic receptor agonist that relaxes airway smooth muscles, producing bronchodilation. Its prolonged effect helps maintain open airways for up to 12 hours, facilitating easier breathing and symptom control.

• Fluticasone Propionate (500 mcg): A potent inhaled corticosteroid that suppresses airway inflammation by inhibiting multiple inflammatory cells and mediators. This reduces airway hyperresponsiveness, edema, and mucus production, improving overall lung function.

Together, these agents provide sustained symptom relief, improved lung function, and reduced frequency of asthma or COPD exacerbations.

Dosage & Administration

Flutisal Inhalation Capsule is intended for inhalation only and should be used with a compatible dry powder inhaler device.

• Recommended dose: One capsule inhaled twice daily or as prescribed by a physician

• Capsules must not be swallowed

• Patients should rinse their mouth with water after inhalation to reduce the risk of oral thrush (candidiasis)

Regular use is essential to achieve optimal therapeutic benefit. Flutisal should not be used as a rescue medication for sudden asthma attacks.

Drug Interactions

• Co-administration with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase systemic exposure to Fluticasone, raising the risk of corticosteroid-related side effects

• Use with other long-acting beta₂-agonists should be avoided

• Beta-blockers may reduce Salmeterol’s bronchodilatory effect

• Concurrent corticosteroid therapy increases the risk of systemic corticosteroid effects

Contraindications

Flutisal is contraindicated in patients with:

• Known hypersensitivity to Salmeterol, Fluticasone Propionate, or any capsule components

• Acute bronchospasm or status asthmaticus requiring immediate relief

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Throat irritation or hoarseness

• Cough

• Oral candidiasis

• Headache

Less common but serious side effects may include:

• Palpitations, tremor, or hypokalemia

• Paradoxical bronchospasm

• Signs of adrenal suppression with prolonged use

Pregnancy & Lactation

Use during pregnancy is recommended only if the potential benefit justifies the risk. Caution is advised during breastfeeding, as corticosteroids may be excreted in small amounts in breast milk.

Precautions & Warnings

• Flutisal is not a rescue inhaler; it does not relieve acute bronchospasm

• Long-term therapy requires monitoring for adrenal suppression, osteoporosis, and growth retardation in children

• Patients should avoid exposure to alcohol or other CNS depressants that may enhance sedative effects

• Regular lung function assessments are recommended to ensure treatment efficacy

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of the reach of children.

Mode of Action

Flutisal works through a dual mechanism: Salmeterol provides prolonged bronchodilation, while Fluticasone Propionate reduces airway inflammation. Together, they improve airflow, decrease airway hyperreactivity, and prevent exacerbations in patients with asthma or COPD.