Glipita-M Tablet 50 mg+1000 mg is a fixed-dose oral antidiabetic combination containing Sitagliptin and Metformin Hydrochloride. It is formulated for the effective management of type 2 diabetes mellitus in adult patients who require combination therapy to achieve optimal blood glucose control. This strength is particularly useful for patients who need a higher dose of metformin along with the complementary incretin-based action of sitagliptin.

Glipita-M Tablet helps control both fasting and postprandial blood glucose levels when used alongside appropriate diet and regular physical activity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

DPP-4 Inhibitor + Biguanide (Antidiabetic Combination)

Pharmacology

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases endogenous incretin hormone levels, such as GLP-1 and GIP. These hormones enhance glucose-dependent insulin secretion from pancreatic beta cells and suppress glucagon release from alpha cells. This results in reduced hepatic glucose production and improved regulation of blood glucose levels without significant risk of hypoglycemia.

Metformin Hydrochloride is a biguanide that primarily reduces hepatic gluconeogenesis, improves insulin sensitivity in peripheral tissues, and decreases intestinal absorption of glucose. It lowers blood glucose levels without stimulating insulin secretion, thereby minimizing the risk of hypoglycemia. The combination of metformin with sitagliptin provides additive and complementary glucose-lowering effects.

Indications

Glipita-M Tablet 50 mg+1000 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Patients inadequately controlled on metformin or sitagliptin monotherapy

• Add-on therapy in combination with diet and exercise

Dosage and Administration

The dosage should be individualized according to the patient’s glycemic status and previous treatment. Glipita-M Tablet is usually taken once or twice daily with meals to reduce gastrointestinal side effects. Treatment initiation and dose adjustments should be done under the supervision of a registered physician.

Benefits and Features

• Dual mechanism of action for effective glycemic control

• Suitable for patients requiring higher metformin dose

• Controls both fasting and postprandial blood glucose

• Low risk of hypoglycemia when used appropriately

• Improves overall metabolic control in type 2 diabetes

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Renal impairment: Use with caution; contraindicated in severe renal dysfunction

• Elderly patients: Renal function should be monitored regularly

• Pregnancy and lactation: Use only if clearly needed and prescribed by a physician

Side Effects

Commonly reported side effects may include:

• Nausea, diarrhea, or abdominal discomfort

• Headache

• Loss of appetite

• Upper respiratory tract infections

Rare but serious adverse reactions such as lactic acidosis or pancreatitis require immediate medical attention.

Precautions and Warnings

• Not indicated for type 1 diabetes mellitus or diabetic ketoacidosis

• Periodic monitoring of renal function and blood glucose is essential

• Temporary discontinuation may be necessary before major surgery or contrast-based diagnostic procedures

Storage

Store in a cool and dry place below 30°C. Protect from light and moisture. Keep out of reach of children.