Heparon Injection 25000 IU/5 ml contains Heparin Sodium, a fast-acting anticoagulant used to prevent and treat blood clots. It works by enhancing the activity of antithrombin III, which inhibits clotting factors and helps maintain smooth blood flow. This injectable formulation is widely used in hospital settings for thromboembolic disorders and during surgical procedures requiring anticoagulation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Heparin Sodium 25000 IU in 5 ml solution

Mechanism of Action

Heparin Sodium acts by potentiating antithrombin III, which inactivates clotting factors such as thrombin (Factor IIa) and Factor Xa. This prevents the conversion of fibrinogen to fibrin, thereby inhibiting clot formation. Its rapid onset of action makes it suitable for acute anticoagulation therapy.

Indications

Heparon Injection is indicated for:

• Prevention and treatment of deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Acute coronary syndrome (as part of treatment protocols)
• Anticoagulation during hemodialysis and extracorporeal circulation
• Prevention of clot formation during surgery or catheterization procedures

Dosage and Administration

• Administered via intravenous (IV) or subcutaneous (SC) injection only under medical supervision
• Dosage is individualized based on clotting parameters (e.g., aPTT monitoring)
• Continuous monitoring of coagulation status is essential
• Dose adjustments are made according to patient response and clinical condition

Contraindications

Heparon Injection should not be used in:

• Active major bleeding or bleeding disorders
• Severe thrombocytopenia (including heparin-induced thrombocytopenia)
• Recent brain, spinal, or eye surgery
• Severe uncontrolled hypertension
• Known hypersensitivity to Heparin

Side Effects

Possible side effects include:

• Bleeding (most common and serious risk)
• Bruising or injection site reactions
• Thrombocytopenia (HIT – Heparin-induced thrombocytopenia)
• Osteoporosis with long-term use
• Elevated liver enzymes
• Hypersensitivity reactions

Precautions

• Regular monitoring of aPTT and platelet count is essential
• Use cautiously in patients with bleeding risk or liver disease
• Avoid intramuscular injections during therapy
• Antidote (Protamine Sulfate) should be available in case of overdose
• Careful dose adjustment is required in elderly patients

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Heparon Injection may interact with:

• Other anticoagulants (warfarin, DOACs) – increased bleeding risk
• Antiplatelet drugs (aspirin, clopidogrel)
• NSAIDs (increased risk of bleeding)
• Thrombolytic agents

Storage Conditions

• Store below 25°C in a cool, dry place
• Do not freeze
• Protect from light
• Keep out of reach of children.