Informet LA Tablet 500 mg is a long-acting oral antidiabetic medication containing metformin hydrochloride in a modified-release formulation. It is designed to provide sustained glycemic control throughout the day with improved gastrointestinal tolerability compared to immediate-release metformin. Informet LA Tablet is commonly prescribed for the management of type 2 diabetes mellitus, particularly in patients who benefit from once-daily dosing and more stable blood glucose control. It is intended to be used as part of a comprehensive diabetes management program that includes diet, exercise, and regular monitoring.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active ingredient: Metformin Hydrochloride 500 mg

• Dosage form: Long-acting / extended-release tablet

• Route of administration: Oral

Therapeutic Class

• Biguanide antidiabetic agent

Mechanism of Action

Metformin lowers blood glucose levels through multiple complementary mechanisms. It primarily reduces hepatic glucose production by inhibiting gluconeogenesis in the liver. It also enhances insulin sensitivity in peripheral tissues, particularly skeletal muscle, leading to increased glucose uptake and utilization. Additionally, metformin decreases intestinal absorption of glucose. The long-acting formulation releases metformin gradually over an extended period, ensuring steady plasma concentrations, prolonged therapeutic effect, and reduced peaks that may cause gastrointestinal discomfort.

Indications

Informet LA Tablet 500 mg is indicated for:

• Management of type 2 diabetes mellitus in adults

• Patients requiring sustained blood glucose control with improved tolerability

• Use as monotherapy or in combination with other oral antidiabetic drugs or insulin

• Glycemic control when diet and exercise alone are insufficient

Key Benefits

• Provides 24-hour glycemic control with once-daily dosing

• Improved gastrointestinal tolerability compared to immediate-release metformin

• Helps reduce fasting and postprandial blood glucose levels

• Does not cause weight gain and has a low risk of hypoglycemia when used alone

• Suitable for long-term diabetes management

Dosage & Administration

• Dosage should be individualized according to patient needs and response.

• Usually taken once daily with the evening meal or as directed by a physician.

• Tablets should be swallowed whole and not crushed, chewed, or broken.

• Dose titration should be gradual to minimize side effects.

• Regular monitoring of blood glucose and renal function is recommended.

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Precautions & Warnings

• Use with caution in patients with renal or hepatic impairment.

• Renal function should be assessed before initiation and periodically during treatment.

• Temporary discontinuation may be required before major surgery or radiological procedures using iodinated contrast media.

• Contraindicated in patients with severe renal impairment, metabolic acidosis, or conditions associated with hypoxia.

• Patients should inform their healthcare provider about all concomitant medications.

Possible Side Effects

Common side effects may include nausea, diarrhea, abdominal discomfort, and bloating, particularly during the initial phase of treatment. These effects are generally mild and less frequent with the long-acting formulation. Rarely, lactic acidosis may occur, especially in patients with significant renal dysfunction.

Storage

• Store in a cool, dry place away from direct sunlight and moisture.

• Keep out of reach of children.

Conclusion

Informet LA Tablet 500 mg (Metformin Hydrochloride) offers effective and sustained blood glucose control with the convenience of once-daily dosing and improved tolerability. Its long-acting formulation makes it an excellent option for patients seeking consistent glycemic management in type 2 diabetes mellitus.