Intaflam 400 mg is a non-steroidal anti-inflammatory drug (NSAID) formulated for effective relief of pain, inflammation, and fever. It is available in oral dosage forms and as a topical 5% gel, making it suitable for both systemic and localized treatment of a wide range of inflammatory and painful conditions. Intaflam 400 mg works by reducing the production of prostaglandins, the key mediators responsible for pain, swelling, and fever.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Drugs for Osteoarthritis

• Drugs used for Rheumatoid Arthritis

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

Oral Dosage Form:
Intaflam 400 mg oral formulation is indicated for the management of:

• Rheumatoid arthritis

• Osteoarthritis

• Gouty arthritis

• Juvenile polyarthritis

• Ankylosing spondylitis

• Synovitis

• Low back pain

• Dysmenorrhoea

• Fever

• Migraine

• Soft tissue injuries

• Pain and inflammation of dental and musculoskeletal origin

Topical 5% Gel:
Intaflam 400 mg 5% gel is indicated for local relief of pain and inflammation associated with:

• Backache

• Rheumatic and muscular pain

• Sprains and strains

• Sports injuries

• Non-serious arthritic conditions

• Neuralgia (nerve pain)

Pharmacology

Intaflam 400 mg is a non-selective cyclooxygenase (COX) inhibitor that blocks the synthesis of prostaglandins via the arachidonic acid pathway. Its primary anti-inflammatory, analgesic, and antipyretic effects are mainly attributed to inhibition of COX-2, reducing inflammation, pain, fever, and swelling. Inhibition of COX-1 is associated with certain adverse effects, particularly gastrointestinal irritation.
Intaflam 400 mg is administered as a racemic mixture, with in vivo conversion of the R-enantiomer to the more pharmacologically active S-enantiomer.

Dosage and Administration

Oral Administration:

Adults:

• Arthritic conditions: 400 mg, 3–4 times daily, preferably after food

• Maximum daily dose: 2400 mg

• Mild to moderate pain: 400 mg every 6 hours as required

• Dysmenorrhoea: 400 mg every 4 hours as needed

Children:

• Usual dose: 20–30 mg/kg body weight daily in divided doses

• Maximum daily dose should not exceed 2400 mg

• Not recommended for children under 1 year or weighing less than 5 kg

If gastrointestinal discomfort occurs, the medicine should be taken with food or milk.

Topical Administration:

• Apply 4–10 cm of Intaflam 400 mg 5% gel to the affected area

• Massage gently until absorbed

• Use up to 4 times daily, with at least 4 hours between applications

• For external use only on healthy, unbroken skin

• Not recommended for children under 12 years

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Increased risk of gastrointestinal bleeding with warfarin, corticosteroids, SSRIs, and aspirin

• Reduced effectiveness of diuretics, ACE inhibitors, and angiotensin II receptor blockers

• Increased toxicity of lithium and methotrexate

• Increased risk of nephrotoxicity with ciclosporin and tacrolimus

Contraindications

• Known hypersensitivity to Intaflam 400 mg or other NSAIDs

• Active or severe peptic ulcer disease

Side Effects

Commonly reported side effects include:

• Upset stomach

• Nausea

• Vomiting

• Heartburn

Pregnancy and Lactation

Intaflam 400 mg is not recommended during pregnancy or while breastfeeding, unless clearly necessary and prescribed by a physician.

Precautions and Warnings

• Use the lowest effective dose in patients with a history of gastrointestinal ulcer or bleeding

• Long-term use requires periodic ocular monitoring

• Use with caution in patients with asthma, systemic lupus erythematosus, or hypersensitivity to other NSAIDs

Overdose

There is no specific antidote for Intaflam 400 mg. Management includes gastric lavage and correction of electrolyte imbalance if required.

Storage Conditions

Store in a cool, dry place, protected from light.
Keep out of reach of children.