Irita Injection 20 mg/ml contains Irinotecan Hydrochloride, a potent antineoplastic (anti-cancer) agent used in the treatment of certain types of cancers, particularly colorectal cancer. It belongs to the class of medicines known as topoisomerase I inhibitors and is administered intravenously under the supervision of an experienced oncologist.

Irita Injection is commonly used either alone or in combination with other chemotherapeutic agents for the management of advanced or metastatic colorectal cancer. It plays a vital role in modern chemotherapy regimens aimed at slowing tumor growth, shrinking cancer cells, and improving survival outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each ml contains:

• Irinotecan Hydrochloride equivalent to Irinotecan 20 mg

The injection is supplied as a sterile solution for intravenous infusion.

Mechanism of Action

Irinotecan works by inhibiting the enzyme topoisomerase I, which is essential for DNA replication and repair in rapidly dividing cells. By blocking this enzyme, Irinotecan causes DNA damage in cancer cells, preventing them from multiplying and leading to cell death.

Since cancer cells divide more rapidly than most normal cells, they are particularly sensitive to this action. However, some healthy cells may also be affected, which can lead to side effects.

Indications

Irita Injection 20 mg/ml is indicated for:

• Metastatic colorectal cancer

• Advanced colorectal carcinoma

• Combination chemotherapy regimens (such as with fluorouracil and leucovorin)

• Other malignancies as determined by an oncologist

Treatment decisions are based on the type and stage of cancer, previous therapy, and overall patient condition.

Dosage and Administration

• Administered by intravenous infusion only.

• The dose and treatment schedule depend on body surface area, medical condition, and treatment protocol.

• It must be given under strict medical supervision in a hospital or oncology center.

Pre-medication may be required to reduce certain side effects such as nausea or allergic reactions.

Precautions

Before receiving Irita Injection, inform your doctor if you have:

• Liver disease

• Kidney impairment

• History of severe diarrhea

• Bone marrow suppression

• Ongoing infections

Irinotecan is known to cause severe diarrhea, which may occur early or late during treatment. Immediate medical attention is necessary if severe diarrhea develops. Regular blood tests are required to monitor blood cell counts and organ function.

Use in Pregnancy and Lactation

Irinotecan is contraindicated during pregnancy due to the risk of harm to the fetus. Effective contraception should be used during treatment and for a recommended period after therapy. Breastfeeding should be discontinued during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Diarrhea (early or delayed onset)

• Nausea and vomiting

• Hair loss

• Fatigue

• Decreased white blood cell count (neutropenia)

• Anemia

Serious side effects may include severe infection, dehydration, or allergic reactions. Prompt medical intervention is essential if serious symptoms occur.

Storage

Store as directed by the manufacturer, typically below 25°C and protected from light. Keep out of reach of children. The injection should be handled by trained healthcare professionals following safety guidelines.

Irita Injection 20 mg/ml is an important chemotherapeutic agent used in the management of advanced colorectal cancer, providing effective tumor control under specialized medical supervision.