Jakloc XR Tablet 11 mg contains Tofacitinib (extended-release), an oral Janus kinase (JAK) inhibitor used in the management of autoimmune and inflammatory disorders. The extended-release formulation allows once-daily dosing, helping improve patient adherence while maintaining consistent therapeutic effect.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tofacitinib Extended Release (XR) 11 mg

Mechanism of Action

Tofacitinib inhibits Janus kinase (JAK) enzymes, which are responsible for transmitting signals from inflammatory cytokines involved in immune responses. By blocking these pathways, it reduces abnormal immune activity, thereby decreasing inflammation, pain, swelling, and tissue damage in autoimmune diseases.

Indications

Jakloc XR Tablet is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis
• Ankylosing spondylitis
• Ulcerative colitis (moderate to severe)
• Other autoimmune inflammatory conditions as prescribed by a physician

Dosage and Administration

• Taken orally once daily as per physician advice
• Can be taken with or without food
• Swallow whole; do not crush, split, or chew the tablet
• Regular monitoring is required during therapy

Advantages

• Once-daily extended-release formulation improves compliance
• Provides steady drug levels throughout the day
• Helps reduce symptoms of chronic inflammation effectively
• Suitable for long-term management under medical supervision

Possible Side Effects

Common side effects may include:

• Headache
• Diarrhea
• Nausea
• Upper respiratory tract infections
• Increased cholesterol levels

Serious side effects:

• Serious infections (bacterial, viral, fungal)
• Tuberculosis reactivation
• Blood clots (DVT, pulmonary embolism)
• Liver enzyme elevation
• Reduced white blood cell or platelet counts

Precautions

• Screen for tuberculosis before starting treatment
• Regular monitoring of CBC, liver function, and lipid profile is required
• Avoid live vaccines during treatment
• Use cautiously in patients with infection history
• Not recommended during pregnancy unless clearly necessary

Contraindications

• Known hypersensitivity to Tofacitinib or any component
• Active serious infections
• Severe hepatic impairment

Drug Interactions

• Strong CYP3A4 inhibitors may increase drug levels
• Strong CYP3A4 inducers may reduce effectiveness
• Concomitant immunosuppressants may increase infection risk
• Avoid live vaccines during therapy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 30°C
• Protect from moisture and direct sunlight
• Keep out of reach of children

Important Notes

Jakloc XR Tablet 11 mg provides once-daily extended-release therapy for autoimmune diseases, offering improved convenience and consistent symptom control. It should only be used under strict medical supervision with regular monitoring for safety.