Jardimet XR Tablet 10 mg + 1000 mg is an extended-release fixed-dose combination of Empagliflozin and Metformin Hydrochloride, developed for the effective management of type 2 diabetes mellitus in adults. This formulation combines two complementary glucose-lowering agents in a once-daily regimen, helping patients achieve sustained glycemic control with improved convenience and tolerability.

Metformin Hydrochloride is a first-line antidiabetic agent that works by reducing hepatic glucose production, decreasing intestinal glucose absorption, and enhancing peripheral insulin sensitivity. Empagliflozin belongs to the Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitor class and lowers blood glucose by increasing the elimination of excess glucose through urine. The extended-release (XR) formulation of metformin ensures gradual drug release, maintaining stable plasma levels and reducing gastrointestinal side effects commonly associated with immediate-release metformin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each extended-release tablet contains:

• Empagliflozin 10 mg

• Metformin Hydrochloride 1000 mg (Extended Release)

Therapeutic Class

• Antidiabetic Agents

• SGLT2 Inhibitor + Biguanide (Extended-Release Combination)

Indications and Uses

Jardimet XR Tablet 10 mg + 1000 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adult patients

• Patients inadequately controlled with metformin alone or combination therapy

• Adjunct to diet and exercise for improved blood glucose control

• Long-term diabetes management requiring higher-dose metformin with once-daily dosing

Mechanism of Action

Metformin XR lowers blood glucose by inhibiting hepatic gluconeogenesis, improving insulin sensitivity, and reducing intestinal glucose absorption. Empagliflozin inhibits the SGLT2 transporter in the kidneys, decreasing glucose reabsorption and promoting urinary glucose excretion. The combined action results in effective, insulin-independent glycemic control.

Key Benefits

• Dual-action therapy for enhanced glycemic control

• Extended-release metformin improves gastrointestinal tolerability

• Once-daily dosing supports better treatment adherence

• Low risk of hypoglycemia when used appropriately

• Helps support weight management and metabolic balance

Dosage and Administration

• Usually taken once daily with food

• Tablets should be swallowed whole and not crushed or chewed

• Dose adjustments are based on blood glucose response and renal function

• Regular monitoring of blood sugar and kidney parameters is recommended

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis

• Use with caution in patients with renal or hepatic impairment

• Maintain adequate hydration to reduce the risk of dehydration

• Rare risk of lactic acidosis associated with metformin

• Avoid excessive alcohol intake during treatment

Adverse Effects

Common side effects may include nausea, diarrhea, abdominal discomfort, increased urination, urinary tract infections, and genital fungal infections. These effects are generally mild and tend to decrease with continued use.

Storage Conditions

• Store below 30°C in a dry place

• Protect from moisture and direct sunlight

• Keep out of reach of children

Conclusion

Jardimet XR Tablet 10 mg + 1000 mg (Empagliflozin + Metformin Hydrochloride) provides an effective once-daily combination therapy for adults with type 2 diabetes mellitus. Its extended-release formulation and dual mechanism of action help achieve consistent blood glucose control while supporting long-term treatment adherence under medical supervision.