Koloride Injection (Cholera Saline) is a sterile intravenous fluid formulation used for the rapid correction of fluid and electrolyte loss in patients suffering from severe dehydration, particularly due to cholera and acute diarrheal illnesses. Cholera saline is specially formulated to closely match the electrolyte losses seen in profuse watery diarrhea, making it a critical component in emergency and hospital-based rehydration therapy.

Koloride Injection plays a vital role in restoring circulating blood volume, correcting electrolyte imbalance, and preventing life-threatening complications associated with severe dehydration and hypovolemic shock.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition and Rationale

Cholera saline is an isotonic solution containing essential electrolytes such as:

• Sodium

• Chloride

• Potassium

• Bicarbonate or bicarbonate precursors (depending on formulation)

This specific electrolyte composition is designed to replace the large amounts of sodium, chloride, potassium, and base lost in stool during cholera and similar diarrheal diseases. The presence of bicarbonate helps correct metabolic acidosis, a common complication in severe dehydration.

Mechanism of Action

Koloride Injection works by:

• Rapidly replenishing intravascular fluid volume

• Restoring electrolyte balance

• Correcting acid–base disturbances

• Improving tissue perfusion and organ function

Intravenous administration ensures immediate availability of fluids and electrolytes, which is essential in patients who are unable to tolerate oral rehydration or are in shock.

Therapeutic Indications

Koloride Injection is indicated for:

• Severe dehydration due to cholera

• Acute watery diarrhea with massive fluid loss

• Hypovolemic shock resulting from gastrointestinal fluid depletion

• Severe electrolyte imbalance requiring rapid correction

• Emergency rehydration when oral rehydration therapy is insufficient or not feasible

It is commonly used in hospital settings, emergency departments, and intensive care units.

Dosage and Administration

• Koloride Injection should be administered intravenously under strict medical supervision.

• The rate and volume of infusion depend on the patient’s age, body weight, degree of dehydration, and clinical condition.

• Frequent monitoring of vital signs, urine output, and electrolyte levels is recommended during therapy.

• Once the patient stabilizes, therapy may be transitioned to oral rehydration solutions as appropriate.

Dosage adjustments are made based on ongoing fluid losses and laboratory parameters.

Safety Information and Precautions

• For intravenous use only.

• Must be used with caution in patients with renal impairment, cardiac disease, or electrolyte abnormalities unrelated to diarrhea.

• Over-infusion may lead to fluid overload or electrolyte disturbances.

• Regular monitoring of serum electrolytes and acid–base status is advised during prolonged use.

• The solution should be visually inspected before use and discarded if particulate matter or discoloration is observed.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

When used appropriately, Koloride Injection is generally well tolerated. However, potential risks may include:

• Fluid overload

• Electrolyte imbalance

• Local reactions at the injection site

Adverse effects are usually related to improper dosing or inadequate monitoring.

Storage Instructions

• Store at room temperature as recommended.

• Protect from excessive heat and direct sunlight.

• Do not freeze.

• Keep out of reach of children.

Key Benefits of Koloride Injection

• Specifically formulated for cholera-related dehydration

• Rapid restoration of fluid and electrolyte balance

• Helps prevent shock and life-threatening complications

• Essential emergency rehydration solution in severe diarrhea

Koloride Injection (Cholera Saline) is a lifesaving intravenous fluid therapy designed for the effective management of severe dehydration due to cholera and acute diarrheal conditions, ensuring prompt stabilization and recovery when administered under proper medical care.