Lasgrain Tablet 100 mg contains Lasmiditan Hemisuccinate, a novel, centrally acting antimigraine medication indicated for the acute treatment of migraine attacks with or without aura in adults. Unlike traditional migraine therapies such as triptans, Lasmiditan does not cause vasoconstriction, making it a suitable option for patients who have cardiovascular risk factors or contraindications to vasoconstrictive agents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Selective Serotonin (5-HT1F) Receptor Agonist
Antimigraine Agent

Indications

Lasgrain Tablet 100 mg is indicated for:

• Acute treatment of migraine with or without aura in adults

Lasgrain is not intended for the prevention of migraine and should not be used for the management of cluster headaches.

Pharmacology

Lasmiditan is a highly selective 5-HT1F receptor agonist. Activation of 5-HT1F receptors inhibits trigeminal nerve pathways involved in migraine pain transmission. Unlike 5-HT1B/1D receptor agonists (triptans), Lasmiditan has no significant vasoconstrictive activity, as 5-HT1F receptors are not located on blood vessels.

By acting centrally within the trigeminal system, Lasmiditan reduces the release of pro-inflammatory neuropeptides and decreases neuronal excitability associated with migraine attacks. This unique mechanism allows effective migraine relief while minimizing cardiovascular risks.

Dosage and Administration

Recommended Dose (Adults):

• 100 mg taken orally as a single dose for acute migraine

• Some patients may benefit from a 50 mg or 200 mg dose depending on clinical response

Maximum Dose:

• Do not exceed one dose within 24 hours

Repeat Dosing:

• Taking a second dose within 24 hours has not been shown to provide additional benefit and is not recommended

Administration Instructions

• Lasgrain Tablet should be swallowed whole with or without food

• Due to potential central nervous system effects, patients should avoid driving or operating machinery for at least 8 hours after taking Lasgrain

Drug Interactions

Caution is advised when Lasgrain Tablet 100 mg is used with:

• Central nervous system depressants (e.g., alcohol, benzodiazepines)

• Serotonergic drugs due to the risk of serotonin syndrome

• Strong P-glycoprotein (P-gp) inhibitors

Concomitant use may increase the risk of sedation and dizziness.

Contraindications

Lasgrain Tablet 100 mg is contraindicated in patients with:

• Known hypersensitivity to Lasmiditan or any of its components

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

The most commonly reported adverse effects include:

• Dizziness

• Somnolence

• Fatigue

• Paresthesia

• Nausea

Less common effects may include lethargy, muscle weakness, and mild cognitive impairment. Most adverse effects are dose-related and transient.

Pregnancy and Lactation

• Pregnancy Category: Data in pregnant women are limited

• Lasgrain should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

• It is unknown whether Lasmiditan is excreted in human milk; caution is advised when administered to breastfeeding women

Precautions and Warnings

• May cause significant central nervous system depression, including sedation

• Patients should be advised not to drive or engage in hazardous activities for at least 8 hours after dosing

• Use caution in patients with a history of substance abuse, as Lasmiditan may cause euphoria in some individuals

Overdose

Symptoms of overdose may include marked dizziness, sedation, and altered mental status. Management should be supportive and symptomatic. There is no specific antidote.

Storage Conditions

Store below 30°C, protected from light and moisture.
Keep out of reach of children.

Mode of Action

Lasmiditan selectively activates 5-HT1F receptors in the trigeminal system, inhibiting pain signaling and neurogenic inflammation without causing vasoconstriction. This mechanism provides effective migraine relief while offering an improved safety profile for patients with cardiovascular concerns.