Lemodip Tablet 2.5 mg contains Levamlodipine Maleate, the pharmacologically active S-enantiomer of amlodipine. It is a long-acting calcium channel blocker used primarily in the management of hypertension and certain forms of angina pectoris. By offering effective blood pressure control at a lower dose, Lemodip helps reduce cardiovascular risk while improving patient tolerability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium Channel Blocker (Dihydropyridine)

Pharmacology

Levamlodipine selectively inhibits the influx of calcium ions through L-type calcium channels in vascular smooth muscle cells. Calcium ions are essential for muscle contraction; by blocking their entry, Levamlodipine causes relaxation of peripheral arterioles. This results in reduced peripheral vascular resistance, leading to a gradual and sustained lowering of blood pressure.

Compared to racemic amlodipine, Levamlodipine provides similar antihypertensive efficacy at approximately half the dose, potentially reducing dose-related adverse effects such as peripheral edema.

Pharmacokinetic properties include:

• Absorption: Well absorbed following oral administration

• Bioavailability: High, with minimal first-pass metabolism

• Time to peak concentration: 6–12 hours

• Protein binding: Approximately 98%

• Metabolism: Extensively metabolized in the liver

• Elimination half-life: Long, around 30–50 hours

• Excretion: Primarily via urine as inactive metabolites

Indications

Lemodip Tablet 2.5 mg is indicated for the treatment of:

• Essential hypertension (as monotherapy or in combination with other antihypertensive agents)

• Chronic stable angina pectoris

• Vasospastic (Prinzmetal’s) angina

Effective blood pressure control helps reduce the risk of stroke, myocardial infarction, and other cardiovascular complications.

Dosage and Administration

• Adults: The usual starting dose is 2.5 mg once daily

• Dose may be adjusted based on patient response and clinical condition

• Tablets should be taken orally with water, with or without food

• Once-daily dosing improves patient compliance

Special Populations:

• Elderly patients or those with hepatic impairment may require cautious dose adjustment

• Not recommended for use in children unless advised by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Levamlodipine, Amlodipine, or other dihydropyridine derivatives

• Severe hypotension

• Cardiogenic shock

Side Effects

Lemodip is generally well tolerated. Commonly reported side effects include:

• Headache

• Dizziness

• Flushing

• Peripheral edema

• Fatigue

Less common effects may include palpitations, abdominal discomfort, or nausea.

Precautions and Warnings

• Use with caution in patients with severe hepatic impairment

• Blood pressure should be monitored regularly during therapy

• Sudden discontinuation should be avoided without medical advice

Drug Interactions

Levamlodipine may be safely used with most antihypertensive agents. Caution is advised when co-administered with drugs that significantly affect blood pressure or hepatic metabolism.

Pregnancy and Lactation

• Use during pregnancy only if clearly needed and prescribed by a physician

• Caution is advised during breastfeeding, as small amounts may be excreted in breast milk

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Mode of Action

Lemodip Tablet 2.5 mg lowers blood pressure by selectively blocking calcium entry into vascular smooth muscle, resulting in vasodilation, reduced vascular resistance, and improved cardiac workload without significantly affecting heart rate.