Lifil-A 50000 IU is a high-potency vitamin A preparation used to prevent and treat vitamin A deficiency. Vitamin A is essential for vision, growth, immune function, and the maintenance of healthy skin, hair, and epithelial tissues. Lifil-A 50000 IU is particularly effective in managing ophthalmological conditions like night blindness and xerophthalmia, as well as dermatological and mucosal disorders such as acne vulgaris, ichthyosis, Darier’s disease, and psoriasis.

This preparation supports overall health by promoting proper growth, enhancing resistance to infections, and restoring normal epithelial function. It is also used to meet increased vitamin A demands during recovery from diarrhea, respiratory infections, and for prophylaxis against measles.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Vitamin-A Preparation

Indications

Lifil-A 50000 IU is indicated for:

• Ophthalmologic conditions due to vitamin A deficiency:

  • Night blindness

  • Xerophthalmia

• Dermatological conditions:

  • Changes in skin, hair, and nails

  • Acne vulgaris

  • Ichthyosis

  • Darier’s disease

  • Psoriasis

• Mucosal disorders:

  • Sinusitis

  • Bronchitis

• To meet increased vitamin A requirements during growth, infection, or recovery from diarrhea

• Prophylaxis of measles in children at risk of vitamin A deficiency

Pharmacology / Mode of Action

Vitamin A exists as retinol, retinal, and beta-carotene, which provide reliable antixerophthalmic and growth-promoting activity.

• Vision: Retinal combines with opsin in the retina to form rhodopsin, essential for low-light vision and dark adaptation.

• Cellular Growth: Vitamin A preserves epithelial cell integrity and supports normal growth.

• Immune Function: Enhances resistance to infections by maintaining mucosal integrity.

• Absorption & Storage: Vitamin A is absorbed in the gastrointestinal tract with the aid of bile salts, pancreatic lipase, and dietary fat. It is transported to the liver and stored mainly as retinol palmitate in Kupffer cells for future use.

Dosage and Administration

Severe Deficiency with Corneal Changes:

• 500,000 IU/day for 3 days

• Followed by 50,000 IU/day for 2 weeks

• Then 10,000–20,000 IU/day for 2 months as follow-up therapy

Deficiency without Corneal Changes:

• 10,000–25,000 IU/day until clinical improvement (usually 1–2 weeks)

General Dosage:

• Adults: 50,000–100,000 IU daily; up to 200,000 IU if necessary

• Children (>1 year):

  • Night blindness / Bitot’s spots / Xerophthalmia: 200,000 IU on day 1, 2, and 14

  • Measles: 200,000 IU on day 1 and 2

  • Diarrhea / Respiratory tract infection: 200,000 IU per episode

  • Severe malnutrition: 200,000 IU single dose or as directed by a physician

    রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Avoid long-term daily doses exceeding 5,000 IU during pregnancy

• Use high doses (>50,000 IU) only under medical supervision

• Ensure a vitamin A-free interval after long-term therapy

• Monitor for hypervitaminosis A in prolonged use

Contraindications

• Hypervitaminosis A

• Hypersensitivity to any component of the formulation

Drug Interactions

• Decreased absorption with neomycin

• Increased risk of hypervitaminosis A with synthetic retinoids (acitretin, isotretinoin, tretinoin)

• Increased toxicity risk with alcohol

Possible Side Effects

Excessive intake may cause:

• Irritability, vomiting, headache, and loss of appetite

• Dry, itchy skin, skin desquamation, fatigue, myalgia

• Hair loss, papilledema, nystagmus

• Liver sclerosis and cirrhosis in chronic overdose

Pregnancy & Lactation

• Category A for recommended doses

• Avoid doses exceeding 6,000 IU/day during pregnancy due to risk of fetal malformations

• Breastfeeding mothers: adhere to the U.S. RDA of 5,000 IU

Storage

Store below 25°C in a cool, dry place away from light and moisture. Keep out of reach of children.