Losardil 100/25 Tablet is a combination antihypertensive medication containing Losartan Potassium 100 mg and Hydrochlorothiazide 25 mg. It is designed for adults with hypertension who require potent and sustained blood pressure control, especially when monotherapy with a single agent is insufficient.

Losartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels by inhibiting the effects of angiotensin II, while Hydrochlorothiazide is a thiazide diuretic that reduces excess fluid retention by promoting urine excretion. This combination provides synergistic blood pressure reduction, improves cardiovascular outcomes, and helps protect the kidneys in high-risk patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

The dual action of Losardil 100/25 Tablet ensures effective control of blood pressure:

• Losartan (100 mg):

  • Blocks AT1 receptors, preventing angiotensin II from constricting blood vessels.

  • Promotes vasodilation and reduces systemic vascular resistance.

  • Provides renal protection by reducing glomerular pressure, especially in diabetic patients with proteinuria.

• Hydrochlorothiazide (25 mg):

  • Increases renal excretion of sodium and water, decreasing blood volume.

  • Reduces peripheral resistance, contributing to long-term blood pressure reduction.

  • Helps prevent fluid retention complications in hypertensive patients.

The combination results in enhanced antihypertensive efficacy, particularly for patients not adequately controlled on lower doses or monotherapy.

Indications

Losardil 100/25 Tablet is indicated for:

• Essential hypertension: For adults requiring potent blood pressure management.

• Patients inadequately controlled on monotherapy: Enhances efficacy with dual action.

• Cardiovascular risk reduction: Reduces the risk of stroke, heart attack, and heart failure.

• Renal protection in type 2 diabetes: Slows the progression of kidney disease by reducing proteinuria.

It is not suitable for patients who are pregnant, breastfeeding, or have severe liver or kidney disease, or those with hypersensitivity to Losartan or Hydrochlorothiazide.

Dosage and Administration

• The usual dose is 1 tablet once daily, orally, with or without food.

• Swallow the tablet whole with water; do not crush or chew.

• Blood pressure should be monitored regularly to assess response.

• Dose adjustments may be required for patients with renal or hepatic impairment.

• Lifestyle modifications, including diet, exercise, and reduced salt intake, should be maintained for optimal results.

Precautions

• Avoid during pregnancy, as ARBs may cause fetal harm.

• Monitor kidney function, electrolytes (potassium, sodium), and blood pressure periodically, especially during initial therapy.

• Inform your doctor of all medications being taken, including potassium supplements, other diuretics, or NSAIDs.

• Use caution in patients with low blood pressure, dehydration, or electrolyte imbalances.

• Elderly patients may require closer monitoring due to increased sensitivity to antihypertensive therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Dizziness or lightheadedness

• Fatigue or headache

• Gastrointestinal disturbances such as nausea or abdominal discomfort

• Increased urination due to diuretic effect

Rare but serious side effects include:

• Hyperkalemia (elevated potassium)

• Hypotension (excessive blood pressure reduction)

• Impaired kidney function

• Severe allergic reactions: rash, swelling, difficulty breathing

Seek immediate medical attention if severe symptoms occur.

Storage

Store below 30°C in a dry, cool place, away from direct sunlight and moisture. Keep out of reach of children.

Losardil 100/25 Tablet provides strong and sustained blood pressure control, combining Losartan and Hydrochlorothiazide to protect the heart and kidneys while reducing the risk of cardiovascular complications in hypertensive patients.