Megenox Suspension 200 mg/5 ml is a potent progestin formulation containing Megestrol Acetate, used for the management of various conditions related to appetite stimulation, weight loss, and certain hormone-sensitive cancers. This oral suspension provides an effective and flexible dosing option for adults and pediatric patients who require precise dose adjustment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Progestin / Appetite Stimulant

Indications

Megenox Suspension 200 mg/5 ml is indicated for:

• Management of anorexia, cachexia, or significant weight loss in patients with chronic illnesses such as cancer or AIDS

• Treatment of advanced breast cancer in postmenopausal women

• Palliation in endometrial carcinoma

• Hormone therapy in conditions requiring progestational support

Pharmacology

Megestrol Acetate is a synthetic derivative of progesterone with antineoplastic and appetite-stimulating properties. It acts on the hypothalamic centers in the brain to increase appetite and food intake, which helps in promoting weight gain. In hormone-dependent cancers, Megestrol Acetate exerts its effects by binding to progesterone receptors, reducing the growth and proliferation of malignant cells.

Dosage and Administration

Adults:

• Anorexia, cachexia, or significant weight loss: 400–800 mg daily in divided doses, depending on clinical response

• Hormone-dependent cancers: 40–160 mg daily, orally, or as prescribed by a physician

Pediatrics:

• Dosage is determined based on body weight, age, and clinical condition, under strict medical supervision

Administration Instructions:

• Shake the suspension well before each use

• Measure the prescribed dose using a calibrated dosing spoon or syringe

• Can be taken with or without food

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea, or constipation

• Weight gain and fluid retention

• Hot flashes and sweating

• Headache, dizziness, or fatigue

Less common but serious side effects:

• Thromboembolic events (blood clots)

• Hypertension or edema

• Vaginal bleeding or spotting

• Mood changes, depression, or insomnia

Contraindications

• Hypersensitivity to Megestrol Acetate or any excipients

• History of thromboembolic disorders

• Pregnancy and lactation unless prescribed under strict medical supervision

Precautions & Warnings

• Monitor patients for signs of deep vein thrombosis, pulmonary embolism, or cardiovascular complications

• Use with caution in patients with diabetes, hypertension, liver disease, or edema-prone conditions

• Regular monitoring of weight, blood pressure, and laboratory parameters is recommended during long-term therapy

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with corticosteroids, anticoagulants, or other hormonal therapies

• CYP3A4 inducers and inhibitors can alter drug levels; dosage adjustments may be required

Storage

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Shake well before use and keep out of reach of children

Mode of Action

Megestrol Acetate stimulates appetite through hypothalamic pathways and exerts antineoplastic effects in hormone-sensitive cancers by modulating progesterone receptor activity, reducing tumor growth and promoting patient weight gain.