Megenox Tablet contains Megestrol Acetate 160 mg, a synthetic progestin used in the management of various medical conditions related to hormonal imbalance and appetite regulation. Megestrol Acetate is widely recognized for its anticatabolic and appetite-stimulating effects, making it particularly valuable in oncology and cachexia-related conditions.

Megenox works by interacting with progesterone receptors and other hormonal pathways, providing both therapeutic and palliative benefits in patients suffering from significant weight loss, anorexia, or hormone-sensitive cancers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Megenox Tablet 160 mg is indicated for:

• Anorexia, cachexia, or unexplained weight loss in patients with chronic illnesses, including cancer or AIDS

• Advanced breast cancer in postmenopausal women, particularly where other hormonal therapies are not suitable

• Endometrial carcinoma in cases where surgery or radiotherapy is contraindicated or as adjunct therapy

• Palliative care to improve appetite, body weight, and overall quality of life in patients with chronic wasting conditions

Mechanism of Action

Megestrol Acetate functions as a synthetic progestin, exerting its effects through:

• Binding to progesterone receptors, altering transcription of genes involved in cell proliferation and hormonal signaling

• Appetite stimulation via modulation of hypothalamic pathways, improving caloric intake and weight gain

• Anti-tumor effects in hormone-sensitive cancers by inhibiting estrogen-dependent proliferation of breast and endometrial cancer cells

By combining anabolic and hormonal effects, Megenox helps restore energy balance, improve patient strength, and enhance quality of life in chronic illness or cancer-related wasting.

Dosage and Administration

• Adults: The recommended dose varies depending on the indication:

  • Appetite stimulation / cachexia: 160–320 mg orally once daily, preferably in the morning, with or without food

  • Hormone-sensitive cancers: 160 mg orally once daily, dose adjustment may be required based on response and tolerance

• Tablets should be swallowed whole with water

• Therapy duration depends on clinical response and physician evaluation

• Periodic monitoring of weight, appetite, and laboratory parameters is recommended during treatment

Benefits of Megenox Tablet

• Stimulates appetite and promotes weight gain in patients with wasting conditions

• Improves energy levels and overall well-being

• Provides hormonal therapy for advanced breast or endometrial cancers

• Supports palliative care by enhancing quality of life

• Oral formulation ensures convenient administration

Precautions

• Use cautiously in patients with thromboembolic disorders, diabetes, hypertension, liver disease, or cardiovascular disease

• May cause fluid retention, edema, or weight gain

• Long-term use may require monitoring for adrenal suppression, blood glucose changes, and lipid profile alterations

• Not recommended during pregnancy unless clearly needed, as it may affect fetal development

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Weight gain and fluid retention

• Nausea, vomiting, or diarrhea

• Headache or dizziness

• Breast tenderness or menstrual irregularities

Rare but serious effects may include:

• Thromboembolism or deep vein thrombosis

• Hypertension or cardiac complications

• Adrenal suppression or hormonal imbalance

Storage

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children.