Metazine MR Tablet 35 mg contains Trimetazidine Dihydrochloride, a metabolic anti-ischemic agent used as adjunctive therapy in the management of chronic stable angina pectoris. Unlike conventional anti-anginal drugs that primarily affect heart rate or blood pressure, Trimetazidine works at the cellular level to improve myocardial energy metabolism. Metazine MR is a modified-release formulation designed to provide sustained therapeutic effect with twice-daily dosing, helping improve exercise tolerance and reduce anginal episodes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Trimetazidine Dihydrochloride 35 mg

• Per modified-release tablet

Therapeutic Class

• Metabolic anti-anginal agent

Mechanism of Action

Trimetazidine acts by optimizing cardiac energy metabolism under ischemic conditions. It inhibits fatty acid oxidation and shifts myocardial metabolism toward more efficient glucose utilization. This metabolic shift improves cellular energy production while reducing oxygen consumption, thereby protecting heart muscle cells from ischemic damage. Metazine MR helps maintain normal cardiac function without significantly affecting heart rate, blood pressure, or coronary blood flow.

Indications

Metazine MR Tablet 35 mg is indicated for:

• Adjunctive treatment of chronic stable angina pectoris in patients inadequately controlled or intolerant to first-line anti-anginal therapies

• Improvement of exercise tolerance and reduction in frequency of angina attacks

• Long-term management of ischemic heart disease as prescribed by a cardiologist

Dosage and Administration

The usual recommended dose is one tablet twice daily, taken with meals, or as directed by a healthcare professional. The tablet should be swallowed whole and should not be crushed or chewed, as it is a modified-release formulation. Dosage adjustments may be required in elderly patients or those with renal impairment.

Benefits of Metazine MR Tablet

• Reduces frequency and severity of angina attacks

• Improves exercise capacity and daily activity tolerance

• Provides cellular protection during ischemic episodes

• Does not significantly affect heart rate or blood pressure

• Suitable for long-term adjunctive therapy

Precautions and Warnings

• Not indicated for the treatment of acute angina attacks

• Use with caution in patients with moderate renal impairment

• Not recommended in patients with Parkinson’s disease or movement disorders

• Elderly patients should be monitored regularly

• Use during pregnancy and breastfeeding only if prescribed by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Metazine MR Tablet is generally well tolerated. Some patients may experience mild side effects such as dizziness, headache, nausea, abdominal discomfort, or fatigue. Rarely, movement-related symptoms may occur, which usually resolve after discontinuation of the drug. Patients should seek medical advice if unusual symptoms develop.

Storage

Store Metazine MR Tablet in a cool, dry place away from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiry date stated on the packaging.