Mopride Tablet 1 mg contains Prucalopride Succinate, a selective serotonin (5-HT₄) receptor agonist used primarily in the treatment of chronic constipation, particularly in patients who have not achieved adequate relief from conventional laxatives. It works by enhancing gastrointestinal motility, thereby helping restore normal bowel function.

Mopride Tablet is designed for long-term management of constipation and improves bowel movement frequency, stool consistency, and overall patient comfort. Its targeted mechanism of action makes it a well-tolerated and effective option for patients with persistent symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Mopride Tablet 1 mg is indicated for:

• Treatment of chronic idiopathic constipation in adults

• Patients with constipation who have an inadequate response to laxatives

• Improvement of bowel motility and regular bowel movements

Therapeutic Class

• Gastrointestinal prokinetic agent

• Selective serotonin (5-HT₄) receptor agonist

Pharmacology and Mode of Action

Prucalopride is a highly selective 5-HT₄ receptor agonist that stimulates colonic peristalsis, which is essential for effective bowel movements. Activation of 5-HT₄ receptors enhances the release of neurotransmitters that coordinate smooth muscle contraction in the gastrointestinal tract.

By promoting forward propulsion of intestinal contents, Mopride Tablet helps reduce colonic transit time and improves stool passage without significantly affecting other serotonin receptor subtypes. Its high receptor selectivity contributes to a favorable safety profile with minimal cardiovascular risk compared to older prokinetic agents.

Dosage and Administration

• Recommended adult dose: 1 mg once daily, preferably taken at the same time each day

• The tablet may be taken with or without food

• Dosage may be adjusted by the physician based on patient response and tolerability

Special Populations:

• Elderly patients: Lower starting doses may be considered

• Renal impairment: Dose adjustment may be required in severe renal insufficiency

• Hepatic impairment: No dosage adjustment generally required in mild to moderate impairment

Treatment duration should be guided by clinical response and medical advice.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Prucalopride has a low potential for clinically significant drug interactions. It does not substantially affect cytochrome P450 enzymes and can generally be used alongside commonly prescribed medications. However, caution is advised when used with other drugs that affect gastrointestinal motility or fluid balance.

Patients should inform their healthcare provider about all concomitant medications before starting therapy.

Contraindications

Mopride Tablet 1 mg is contraindicated in patients with:

• Known hypersensitivity to Prucalopride or any excipients

• Intestinal perforation or obstruction

• Severe inflammatory conditions of the gastrointestinal tract

Side Effects

Common side effects include:

• Headache

• Abdominal pain

• Nausea

• Diarrhea

• Dizziness

These effects are generally mild to moderate and tend to occur at the beginning of treatment, often resolving with continued use.

Rare side effects:

• Palpitations

• Mood changes

Patients should seek medical attention if severe or persistent adverse effects occur.

Pregnancy and Lactation

There is limited data on the use of Prucalopride in pregnant women. Mopride Tablet should be used during pregnancy only if clearly needed and prescribed by a physician. Caution is advised during breastfeeding, as it is unknown whether the drug is excreted in human milk.

Precautions and Warnings

• Not intended for acute constipation or bowel obstruction

• Adequate hydration and dietary fiber intake should be maintained during treatment

• Discontinue use and consult a healthcare provider if severe diarrhea or abdominal pain occurs

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.